Human aging is associated with deterioration in physical functional ability. The causes are complex and multifactorial, but are presumed to include the presence and extent of cardiovascular disease. Purpose: To examine the associations between brachial artery (BA) dimensions, flow-mediated dilation (BAFMD) and physical function in 28 older adults (age: 84.6±10.9, range 66 to 98 yrs). Methods: High-resolution ultrasonography was used to measure BA diameters at rest and following 5min of forearm occlusion. Physical function was assessed using the Continuous Scale-Physical Function Performance (CS-PFP) test. Results: Pearson correlation revealed that BAFMD (r =-.39), and all physical function parameters of the CS-PFP declined with age at an alpha of p= .04 and p< .01, respectively (UBS, r= -.69; UBF, r= -.78; LBS, r= -.77; BALCOR, r= -.74; END, r= -.81; PFP total score, r= -.79). Six-minute walk scores (a component of the CS-PFP) also declined with age (r= -.72, p <0.01). Mean BA resting diameter and BAFMD were 4.31±0.77mm and 1.89±1.99%, respectively. Resting diameter was inversely associated with BAFMD (r= -.45, p= .02). Partial correlation (controlling for BMI) was used to account for the influence of participant size on vascular and physical function measures. The results indicated an association between BAFMD and several CS-PFP sub-scales with an alpha of p< .05 (END, r= .40; UBF, r= .39; LBS, r= .39; BALCOR, r= .38). CS-PFP total score (r= .38) and UBS (r= .28) were associated with BAFMD at alpha of p= .06 and p= .18, respectively. Notedly, the difference between resting and peak diameters, as a group, was not significant for the study sample. Two participants in the study sample had BAFMD> 5%, thus the sample was biased towards non-responders. Conclusion: These results appear to confirm predicted trends for physical function decline and reduced vasoreactivity in older adults. Uniquely, this study is the first to suggest a link between BA reactivity and age-appropriate measures of physical functional status. Therefore, BAFMD could potentially provide information regarding the impact of CVD and vasoreactivity on the functional characteristics of the population.
Funded by the Louisiana Board of Regents Millennium Trust Health Education Fund.
[I HEF (2001-06)-02]
| Identifer | oai:union.ndltd.org:LSU/oai:etd.lsu.edu:etd-04142004-111444 |
| Date | 14 April 2004 |
| Creators | King, Christina M. |
| Contributors | Robert Wood, Rebecca Gardner, Michael Welsch |
| Publisher | LSU |
| Source Sets | Louisiana State University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lsu.edu/docs/available/etd-04142004-111444/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to LSU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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