PURPOSE: To examine the influence of the Ultraman triathlon (3 days of non-continuous racing; stage 1: 10 km swim and 144.8 km cycle; stage 2: 275.4 km cycle; stage 3: 84.4 km run) on circulating plasma concentrations of whole-body (CRP, IL-6, and IL-10) and gut-specific inflammatory markers (IL-17 and IL-23) in trained participants, and determine whether these variables influence performance. METHODS: Fourteen triathletes (age: 39 ± 8 yrs; 12 men, 2 women) were evaluated pre-race and post-race for circulating concentrations of CRP, IL-6, IL-10, IL-17, and IL-23. Blood samples were drawn two days prior to stage 1 (1600 h) and one day after stage 3 (1200 h). Plasma biomarker concentrations were determined by ELISA according to manufacturer’s instructions. Data were analyzed with SPSS and significance was accepted at p < 0.05. Values are reported as means ± SD. RESULTS: Plasma CRP significantly increased from pre-race (266.27 ± 276.18 ng/mL) to post-race (25,891.94 ± 12,888.65 ng/mL; p < 0.001). Plasma IL-10 increased from pre-race (3.46 ± 2.98 pg/mL) to post-race (5.15 ± 1.89 pg/mL). Pre-race concentrations of IL-6 were below detectable limits; post-race IL-6 concentrations were 4.00 ± 3.74 pg/mL. Both pre-race and post-race concentrations of IL-17 and IL-23 were below detectable limits. Pearson’s correlation between mean finish time and post-race CRP and post-race IL-10 was 0.35 and 0.54 (p < 0.05), respectively. CONCLUSIONS: The significant increase in CRP during the race may have been due to muscle damage. The greater anti-inflammatory capacity of the athletes likely led to increased clearance of IL-6, IL-17, and IL-23 the day after the race; the increase in IL-10 concentrations during the race reflect this anti-inflammatory response. A significant positive correlation between post-race IL-10 concentrations and mean finish time may indicate that a relationship between anti-inflammatory responses and performance exists. / A Thesis submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Master of Science. / Spring Semester 2018. / March 28, 2018. / Includes bibliographical references. / Michael Ormsbee, Professor Directing Thesis; Lynn Panton, Committee Member; Daniel Van Durme, Committee Member.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_647302 |
| Contributors | Smith, Kyle Andrew (author), Ormsbee, Michael J. (professor directing thesis), Panton, Lynn B. (committee member), Van Durme, Daniel J. (committee member), Florida State University (degree granting institution), College of Human Sciences (degree granting college), Department of Nutrition, Food, and Exercise Science (degree granting departmentdgg) |
| Publisher | Florida State University |
| Source Sets | Florida State University |
| Language | English, English |
| Detected Language | English |
| Type | Text, text, master thesis |
| Format | 1 online resource (86 pages), computer, application/pdf |
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