<div>
<p>Historically, natural products
from plants, fungi, bacteria and animals have played an important role in the
discovery of new drugs. In fact, it has been found that 34% of new FDA-approved
drugs over the last 30 years were derived from natural products or their
derivatives. Because of the chemical and structural diversity of natural
products, they continue to be one of the best options for discovering novel
compounds and scaffolds; this is especially true for compounds targeting the
µ-, δ-, and κ- opioid receptors. However, traditional opioids such as morphine cause
many therapeutically limiting side effects. Therefore, there have been immense
efforts to develop opioids that avoid these side effects, with “signal-biased”
compounds being an intense area of interest. The research presented here investigates
of the biased mechanisms of compounds found in and derived from <i>Mitragyna
speciosa</i>, also known as kratom, and <i>Picralima nitida</i>, also known as
akuamma. Kratom and akuamma compounds are examined for their therapeutic
potential in treating alcohol abuse and pain, respectively, two prevalent
conditions with extreme societal and economic costs.</p>
</div>
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| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/17155409 |
| Date | 19 December 2021 |
| Creators | Anna M Gutridge (11819636) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/EVALUATION_OF_NATURALLY_OCCURRING_OPIOIDS_AND_SYNTHETIC_DERIVATIVES_FOR_THERAPEUTIC_APPLICATION_IN_ALCOHOL_ABUSE_AND_PAIN/17155409 |
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