Hematopoietic stem/progenitor cells (HSPC) play main role in constituting the whole hematopoietic system. Furthermore, since recognized in 1960s, HSPC are utilized to protect patients from severe chemo and radio therapy. As time goes, they are also used to treat hematopoietic disorders such as leukemia. Bone marrow, peripheral blood and umbilical cord blood are now the three sources of HSPC. Umbilical cord blood seems optimal because it is easy to obtain, no risk to graft donor and low probability of infection transmission. However, low number of HSPCs in umbilical cord blood is the main limitation. My research focuses mainly on in-vitro proliferation of HSPCs. In addition, I also worked on labeling HSPC in-vitro for tracking these cells after transplantation. The experimental results indicated that HSPCs are effectively labeled and their proliferation rate is significantly enhanced in-vitro. / N/A
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:AEU.10048/1855 |
| Date | 06 1900 |
| Creators | Xu, Peng |
| Contributors | Dr.Jie Chen (ECE&BME), Dr. Jie Chen (ECE&BME), Dr.Jame Xing (Laboratory medicine and pathology), Dr.Hasan Uludag (CME&BME) |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | 2185028 bytes, application/pdf |
| Relation | 1. “Magnetic carbon nanotube labelling for haematopoietic stem/progenitor cell tracking”. Hilal Gul, Weibing Lu, Peng Xu, James Xing and Jie Chen, 2010 Nanotechnology 21 155101 |
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