Overall, this study enhances our understanding of the role of c-Myc activation in chromosome 11 repositioning in mouse PreB v-abl/myc cells and a possible interaction between telomeres, TRF2, and lamin A/C underlying this phenomenon. Additionally, the importance of human 17q25.3 is confirmed as a potential region involved in NSCLC tumorigenesis. A utilizationof the 3D telomeric organization profiles is demonstrated a tendency to categorize NSCLC patients into different prognostic subgroups, underscoring a potential future value of its clinical application. / February 2017
| Identifer | oai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/32080 |
| Date | 27 January 2017 |
| Creators | Sunpaweravong, Patrapim |
| Contributors | Mai, Sabine (Human Anatomy and Cell Science), Vrontakis, Maria (Human Anatomy and Cell Science) Hombach-Klonisch, Sabine (Human Anatomy and Cell Science) Simard, Louise (Biochemistry and Medical Genetics) |
| Source Sets | University of Manitoba Canada |
| Detected Language | English |
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