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Ethyl pyruvate combats human leukemia cells but spares normal blood cells

Ethyl pyruvate, a known ROS scavenger and anti-inflammatory drug was found to combat leukemia cells. Tumor cell killing was achieved by concerted action of necrosis/apoptosis induction, ATP depletion, and inhibition of glycolytic and para-glycolytic enzymes. Ethyl lactate was less harmful to leukemia cells but was found to arrest cell cycle in the G0/G1 phase. Both, ethyl pyruvate and ethyl lactate were identified as new inhibitors of GSK-3β. Despite the strong effect of ethyl pyruvate on leukemia cells, human cognate blood cells were only marginally affected. The data were compiled by immune blotting, flow cytometry,
enzyme activity assay and gene array analysis. Our results inform new mechanisms of ethyl pyruvate-induced cell death, offering thereby a new treatment regime with a high therapeutic window for leukemic tumors.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-213853
Date22 November 2016
CreatorsBirkenmeier, Gerd, Hemdan, Nasr Y. A., Kurz, Susanne, Bigl, Marina, Pieroh, Philipp, Debebe, Tewodros, Buchold, Martin, Thieme, Rene, Wichmann, Gunnar, Dehghani, Faramarz
ContributorsUniversität Leipzig, Medizinische Fakultät, Universität Leipzig, Medizinische Fakultät, Universität Leipzig, Medizinische Fakultät, Public Library of Science,
PublisherUniversitätsbibliothek Leipzig
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:article
Formatapplication/pdf
SourcePLoS ONE 11(8): e0161571 doi:10.1371/journal.pone.0161571

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