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Quantitation of iron in the liver, pancreas and heart of hospital patients in Hong Kong.

by Yim-kam Kwong. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1993. / Includes bibliographical references (leaves 119-133). / ACKNOWLEDGEMENT --- p.vii / LIST OF TABLES --- p.viii / LIST OF FIGURES --- p.x / ABSTRACT --- p.1 / SECTION / Chapter 1. --- INTRODUCTION --- p.3 / Chapter 2. --- LITERATURE REVIEW --- p.6 / Chapter 3. --- MATERIALS AND METHODS --- p.39 / Chapter 4. --- RESULTS --- p.61 / Chapter 5. --- DISCUSSION --- p.103 / Chapter 6. --- CONCLUSION --- p.116 / REFERENCES --- p.119 / APPENDIX --- p.134 / Chapter SECTION 1 --- INTRODUCTION --- p.3 / Chapter SECTION 2 --- LITERATURE REVIEW --- p.6 / Chapter 2.1 --- IRON --- p.6 / Chapter 2.1.1 --- CHEMISTRY --- p.6 / Chapter 2.1.2 --- METABOLISM --- p.6 / Chapter 2.1.2.1 --- Homeostasis --- p.6 / Chapter 2.1.2.2 --- Absorption --- p.8 / Chapter 2.1.2.3 --- Transportation - Role of transferrin in iron transport --- p.9 / Chapter 2.1.2.4 --- Storage --- p.10 / Ferritin --- p.11 / Haemosiderin --- p.13 / Chapter 2.2 --- IRON OVERLOAD --- p.14 / Chapter 2.2.1 --- AETIOLOGY --- p.14 / Chapter 2.2.2 --- PREVALENCE --- p.15 / Chapter 2.2.3 --- MECHANISM --- p.16 / Chapter 2.2.4 --- PATHOLOGY OF IRON OVERLOAD --- p.17 / Chapter 2.2.4.1 --- Increased absorption of iron from the diet --- p.18 / Chapter 2.2.4.2 --- Parenteral administration of excess iron --- p.21 / Chapter 2.2.4.3 --- Increased iron absorption combined with transfusional overload --- p.22 / Chapter 2.2.4.4 --- Miscellaneous conditions --- p.23 / Chapter 2.2.5 --- CLINICAL PRESENTATION --- p.24 / Chapter 2.2.6 --- EFFECT OF IRON OVERLOAD --- p.25 / Chapter 2.2.6.1 --- Role of iron in lipid peroxidation --- p.25 / Chapter 2.2.6.2 --- Iron and neoplasia --- p.26 / Chapter 2.3 --- ASSESSMENT OF IRON OVERLOAD --- p.26 / Chapter 2.3.1 --- NON-SERUM PARAMETER --- p.26 / Chapter 2.3.1.1 --- Localization of stored iron --- p.27 / Chapter 2.3.1.2 --- Morphometric assessment of hepatic iron in liver biopsy --- p.30 / Chapter 2.3.1.3 --- Hepatic iron concentration --- p.31 / Chapter 2.3.1.4 --- Atomic absorption spectrophotometry --- p.32 / Chapter 2.3.1.5 --- Hepatic imaging studies --- p.33 / Chapter 2.3.2 --- SERUM PARAMETERS --- p.34 / Chapter 2.3.2.1 --- Serum ferritin measurement --- p.34 / Chapter 2.3.2.2 --- Serum iron --- p.36 / Chapter 2.3.2.4 --- Transferrin saturation --- p.37 / Chapter SECTION 3 --- MATERIALS AND METHOD --- p.39 / Chapter 3.1 --- SUBJECTS --- p.39 / Chapter 3.1.1 --- SOURCE OF TISSUE SAMPLES AND CASE SELECTION --- p.39 / Chapter 3.1.1.1 --- The controls --- p.39 / Chapter 3.1.1.2 --- The transfusion group --- p.39 / Chapter 3.1.1.3 --- The non-transfusion group --- p.40 / Chapter 3.1.1.4 --- The total group --- p.40 / Chapter 3.2 --- METHODS --- p.40 / Chapter 3.2.1. --- HISTOLOGICAL METHOD --- p.44 / Chapter 3.2.1.1 --- Haematoxylin and Eosin Stain --- p.47 / Chapter 3.2.1.2 --- Perls' Prussian Blue Method --- p.49 / Chapter 3.2.1.3 --- The Rowe's Method of Iron Deposition --- p.47 / Chapter 3.2.1.4 --- Method 1 --- p.48 / Chapter 3.2.1.5 --- Method2 Estimation and grouping of % area --- p.49 / Chapter 3.2.1.6 --- "Comparison of Rowe's method, and the two histological iron grading methods" --- p.54 / Chapter 3.2.2 --- CHEMICAL MEASUREMENT --- p.55 / Chapter 3.2.2.1 --- Sectioning of paraffin liver blocks for chemical measurement --- p.55 / Chapter 3.2.2.2 --- Paraffin removal --- p.56 / Chapter SECTION 4 --- RESULTS --- p.61 / Chapter 4.1 --- HISTOLOGICAL ASSESSMENT --- p.61 / Chapter 4.1.1 --- HISTOLOGICAL STUDY --- p.61 / Chapter 4.1.2 --- SEX DISTRIBUTION --- p.65 / Chapter 4.1.3 --- AGE DISTRIBUTION --- p.65 / Chapter 4.2 --- CHEMICAL MEASUREMENT --- p.81 / Chapter 4.2.1 --- EVALUATION OF ANALYTICAL PRECISION --- p.84 / Chapter 4.2.2 --- RESULT OF CHEMICAL MEASUREMENTS --- p.81 / Chapter 4.2.3 --- ASSOCIATED CONDITIONS IN PATIENTS WITH LIVER TISSUE IRON > 50 μMOL/G --- p.86 / Chapter 4.3 --- CORRELATION OF HISTOLOGICAL ASSESSMENT WITH CHEMICAL MEASUREMENT --- p.88 / Chapter 4.3.1 --- CORRELATION OF HISTOLOGICAL ASSESSMENT WITH CHEMICAL MEASUREMENT BY METHOD 1 --- p.88 / Chapter 4.3.2 --- CORRELATION OF ASSESSMENT WITH CHEMICAL MEASUREMENT BY METHOD 2 --- p.89 / Chapter 4.3.2.1 --- Percentage area --- p.95 / Chapter 4.3.2.2 --- Score --- p.96 / Chapter 4.4 --- PANCREATIC AND MYOCARDIAC HAEMOSIDEROSIS --- p.100 / Chapter 4.4.1 --- METHOD 2 --- p.100 / Chapter SECTION 5 --- DISCUSSIONS --- p.103 / Chapter SECTION 6 --- CONCLUSIONS --- p.116 / REFERENCES --- p.119 / APPENDIX --- p.134

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_319251
Date January 1993
ContributorsKwong, Yim-kam., Chinese University of Hong Kong Graduate School. Division of Clinical and Pathological Sciences.
PublisherChinese University of Hong Kong
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, xii, 200 leaves : ill. (some mounted col.) ; 30 cm.
CoverageHong Kong
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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