Objetivo General: Identificar el perfil clínico y de laboratorio al momento del diagnóstico del lupus eritematoso sistémico (LES) en pacientes del Hospital Nacional Arzobispo Loayza (HNAL) del 2009-2013. Metodología: Estudio descriptivo, observacional, transversal. La población estudiada fueron pacientes del HNAL con el diagnóstico de LES del 2009-2013. Se registró información de las historias clínicas mediante una ficha de recolección de datos validada mediante juicio de expertos. Los resultados fueron analizados utilizando el paquete estadístico SPSS 20, y presentados mediante medias, medianas y rango intercuartilar (RIC). Resultados: 67 pacientes con edad promedio de 34±13 años al momento del diagnóstico. Las medianas del tiempo de enfermedad previo al diagnóstico y de demora al diagnóstico fueron 3 (RIC 1-6) y 0 (RIC 0-1) meses, respectivamente. Todos los pacientes presentaron síndrome general. Las manifestaciones clínicas más frecuentes fueron artritis/sinovitis (65,7%), alopecia sin cicatrices (25,4%) y fotosensibilidad (22,4%). Las manifestaciones de laboratorio más frecuentes fueron anticuerpo antinuclear positivo (83,6%) linfopenia e hipocomplementemia (ambos con 62,7%). La distribución del cumplimiento de criterios del American College of Rheumatology (ACR) y Systemic Lupus International Collaborating Clinics (SLICC) fue del 67,2% y 80,6%, respectivamente. La mediana del número de criterios ACR y SLICC al diagnóstico fue 4 (RIC 3-5) y 5 (RIC 4-6), respectivamente; 31,3% presentaron exclusivamente criterio médico para el diagnóstico. Conclusiones: Las principales manifestaciones implican alteraciones sistémicas y órgano-específicas, como hematológicas, articulares e inmunológicas. Se resalta la importancia del criterio médico para el diagnóstico de LES en la práctica clínica. / General Objective: To identify clinical and laboratory characteristics at diagnosis of systemic lupus erythematosus (SLE) at Hospital Nacional Arzobispo Loayza (HNAL) since 2009 to 2013. Methodology: Descriptive, observational and cross-type study. Population studied were patients with the diagnosis of SLE in the register of the Department of Statistics of the Hospital National Arzobispo Loayza among 2009 to 2013. Information from medical records was recorded by a data collection sheet validated by expert judgment, analyzing with SPSS 20.0 Results: 67 patients with an average age of 34±13 years were included. Median time to disease prior to diagnosis and delay to diagnosis were 3 (IQR 1-6) and 0 (IQR 0-1) months, respectively. All the patients had general syndrome. The most common clinical manifestations were arthritis/synovitis (65.7%), photosensitivity (22.4%) and alopecia unscarred (25.4%). The most frequent manifestations of laboratory features were title positive for antinuclear antibody (83.6%), lymphopenia and hypocomplementemia (bother with 62.7%). The compliance of criteria of the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) was 67.2% and 80.6%, respectively. The median of criteria at diagnosis for ACR and SLICC was 4 (IQR 3-5) and 5 (IQR 4-6), respectively. On the other hand, 31.3% of the patients were diagnosis purely by medical criteria for the diagnosis of SLE. Conclusions: The main manifestations involve systemic and specific alterations, as hematological, joint and immune. Furthermore, it is relevant the importance of the medical criteria for diagnosis of SLE at the clinical practice.
Keywords: systemic lupus erythematosus, half-blood, diagnosis. / Tesis
| Identifer | oai:union.ndltd.org:Cybertesis/oai:cybertesis.unmsm.edu.pe:cybertesis/4335 |
| Date | January 2015 |
| Creators | Veramendi Espinoza, Eliana |
| Contributors | Meneses Flores, Giovanni Giuseppe Simón |
| Publisher | Universidad Nacional Mayor de San Marcos |
| Source Sets | Universidad Nacional Mayor de San Marcos - SISBIB PERU |
| Language | Spanish |
| Detected Language | Spanish |
| Type | info:eu-repo/semantics/bachelorThesis |
| Format | application/pdf |
| Source | Repositorio de Tesis - UNMSM, Universidad Nacional Mayor de San Marcos |
| Rights | info:eu-repo/semantics/openAccess |
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