The AKR strain of mice have a genetic trait for spontaneous development of lymphocytic leukemia. In this study, leukemic mice were found to have significantly larger (p<0.01) thymuses and spleens than preleukemic mice. The enlarged leukemic tissues were densely packed with a light staining cell, with a hollow-appearing nucleus. Tissues from preleukemic mice were observed to be infiltrated with a smaller, darker-staining lymphocyte. Fluorescent antibody staining was done on preleukemic and leukemic tissues, using three antisera against murine lymphocyte theta antigen, and an antiserum against murine IgG. Significantly brighter fluorescence, (p <0.05) with theta-specific antisera, was found in leukemic thymuses,spleens, and kidneys than in the same preleukemic tissues. Leukemic tissues had significantly brighter fluorescence (p <0.05) than preleukemic tissues with IgG antiserum.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc503886 |
| Date | 05 1900 |
| Creators | Michnoff, Carolyn A. |
| Contributors | Hatten, Betty A., Norton, S. J., Kester, Andrew S. |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | v, 117 leaves : ill., Text |
| Rights | Public, Michnoff, Carolyn A., Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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