>Magister Scientiae - MSc / Marine invertebrate associated (MIA) bacteria are an important source of bioactive secondary metabolites with the potential to address the current anti-microbial resistance crisis experienced globally. Secondary metabolites (SM) have historically yielded several compounds with pharmaceutical applications such as anti-viral, anti-microbial, anti-cancer, anti-inflammatory and anti-parasitic. This study aimed to use bioassay and genomic approaches in the identification of MIA bacteria isolated from South African marine invertebrates as a source of bioactive compounds and the characterisation of the produced SMs using analytical techniques. A total of 23 MIA bacteria were cultured under different conditions (one strain many compounds approach (OSMAC)) to evaluate their ability to produce anti-microbial compounds against a panel of indicator strains namely Escherichia coli 1699, Bacillus cereus ATCC10702, Pseudomonas putida ATCC12633, Mycobacterium aurum A+, Staphylococcus epidermidis ATCC14990, Aspergillus fumigatus MRC and Candida albicans NIOH.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/9014 |
| Date | January 2021 |
| Creators | Mhlongo, Jatro Kulani |
| Contributors | Trindade, Marla |
| Publisher | University of Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Format | application/pdf |
| Rights | University of Western Cape |
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