Background: Chronic Kidney Disease (CKD) is public health problem. Meta-analyses and systematic reviews show that exposure to psychosocial stressors at work is associated with cardiometabolic impairment. However, little is known about the effect of these stressors on kidney health. Aims: The aim of this study was to determine the association between psychosocial stressors at work, defined according to the effort-reward imbalance model, and renal biomarkers (glomerular filtration rate (eGFR) and albuminuria-creatininuria ratio (ACR)).Methods: This is a prospective cohort study, initially conducted among 9188 white-collarworkers in Quebec City, Canada with two follow-ups, one after 8 years (T2: 1999-2000) and one after 24 years (T3: 2015-2018). A subsample of 1383 participants (workers and retirees) was selected for renal biomarkers assessment at the last follow-up. Effort-reward imbalance and over commitment at work were assessed at T2 using validated scales. Glomerular filtration rate and albuminuria-creatininuria ratio were measured during last follow-up (T3).Multiple linear regression was used. Models were sequentially adjusted for socioeconomic,cardiovascular and lifestyle factors, as well as other psychosocial stressors. Results: In the fully adjusted model, workers in the highest level (upper than median) of overcommitment had a lower eGFR [mean difference=-1.9 ml/min; IC95%: -3.2; -0.6];p=0,001 when compared to those in the lowest level. No association was observed between albuminuria-creatininuria ratio and effort-reward imbalance exposure.Conclusion: In the present study, past exposure to overcommitment at work was associated with lower glomerular filtration rate. To our knowledge, this is the first study to examine this association. Future research is needed to clarify to role of psychosocial stressors at work on renal markers.
| Identifer | oai:union.ndltd.org:LAVAL/oai:https://corpus.ulaval.ca:20.500.11794/100263 |
| Date | 15 September 2022 |
| Creators | Attisso, Eugène |
| Contributors | Trudel, Xavier, Brisson, Chantal |
| Source Sets | Université Laval |
| Language | French |
| Detected Language | English |
| Type | COAR1_1::Texte::Thèse::Mémoire de maîtrise |
| Format | 1 ressource en ligne (x, 87 pages), application/pdf |
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