A detailed dosimetric comparison between Inverse Planning by Simulated Annealing (IPSA) and Dose Points (DP) optimized treatment plans has been performed
for High Dose Rate (HDR) brachytherapy of skin lesions using Freiburg Flap applicator
in order to find out whether or not IPSA offers better clinical dosimetric outcomes for
lesions categorized into four different curvatures. Without compromising target coverage,
IPSA reduced the volume of Planning Target Volume (lesion) that received at least 125%
of the prescription dose on average by 41%. It also reduced the volume of the healthy
skin surrounding the lesion that receives at least 100% of the prescription dose on
average by 42%. IPSA did not show any advantage over DP in sparing normal structures
underlying the lesions treated. Although DP optimization algorithm has been regularly
used at Lynn Cancer Institute for HDR brachytherapy of skin lesions, recent upgrades in IPSA software have made IPSA more amenable to rapid treatment planning and therefore
IPSA can be used either in place of DP or as its alternative. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2014. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_30774 |
| Contributors | Ghebremichael, Bereket Tewolde (author), Ouhib, Zoubir (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Physics |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 102 p., application/pdf |
| Rights | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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