Includes abstract. / Includes bibliographical references. / Milk molecules such as mucins, antibodies, bactericidal enzymes like lysozymes and fatty acids that lyse bacteria, viral particles and bacterial peptides, offer anti-microbial activity in milk. Despite human breast milk being rich in anti-microbial substances, such as mucin, that protect against pathogens and viruses, it remains a significant route of HIV transmission from mother to child. ... The objectives of the study were to isolate, purify, identify and investigate the anti-HIV-1 activity of crude breast milk particularly the human milk fat globule material (MFGM) and its purified mucin components, in HIV positive patients (n = 20) compared with those who are not infected (n = 20). This study also tested the effect that heat (80°C, 10 min) might have on breast milk which might release the milk mucins and consequently have an inhibitory effect on HIV-1.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/11999 |
| Date | January 2012 |
| Creators | Mthembu, Yolanda |
| Contributors | Mall, Anwar Suleman |
| Publisher | University of Cape Town, Faculty of Health Sciences, Department of Surgery |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Master Thesis, Masters, MSc |
| Format | application/pdf |
Page generated in 0.1816 seconds