<p>The genetic region which exerts a major influence on graft rejection is known as the major histocompatibility complex or MHC. The MHC in man, the HLA system, includes at least five distinct multi-allelic loci, HLA-A,-B,-C,-D and -DR. The HLA system possesses three fundamental characteristics: it is highly polymorphic; its alleles are in linkage disequilibrium with one another as well as with other loci; and the HLA antigens demonstrate extensive cross-reactivity.</p> <p>A number of previous reports have established associations between certain HLA-B antigens and juvenile-onset insulin-dependent diabetes mellitus (JOD). In this investigation we have studied the distribution of HLA antigens in patients with diabetes mellitus with a special emphasis on HLA antigens belonging to the DR locus. We observed a significant increase in the incidence of HLA-DR4 in JOD patients as compared to its frequency in the normal controls. The present data also confirm earlier reports of the increased incidence of HLA-B15, -B40 and -CW3 in the patient group. Further analyses of the data showed that the primary association of JOD was with HLA-DR4 and the associations with the HLA-B and -C loci antigens were secondary in nature.</p> / Master of Science (MS)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/7607 |
| Date | 11 1900 |
| Creators | Solow, Lucius Henry |
| Contributors | Singal, D.P., Medical Sciences (Blood and Cardiovascular) |
| Source Sets | McMaster University |
| Detected Language | English |
| Type | thesis |
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