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In Situ Hybridization of 70 kD Heat Shock Protein mRNA in a Rat Model of Ethanol Self-Administration

Sucrose fading was used to initiate self-administration of ethanol on an FR4 schedule in male Fischer 344 rats. Rats showed low response rates for ethanol alone. After administration of liquid diet containing ethanol, ethanol intake increased over levels prior to administration of the liquid diet. In situ hybridization compared mRNA for the inducible or constitutive 70 kD heat shock proteins in ethanol and nonethanol rats. Both inducible and constitutive mRNAs were found in nonethanol and ethanol tissues. In peripheral organs, radiolableling was higher in ethanol tissue. In brain regions, nonethanol tissues showed higher radiolabeling.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc332564
Date12 1900
CreatorsOtt-Reeves, Ellen (Ellen Theresa)
ContributorsLane, John, Forster, Michael J., Sherman, J. Mark
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatxi, 125 leaves : ill., Text
RightsPublic, Ott-Reeves, Ellen (Ellen Theresa), Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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