Epithelial adhesion molecule, E-cadherin plays important role in maintaining structural integrity of epithelial tissue. Altered expression of E-cadherin might result in the loss of contact inhibition growth property, abnormal cell growth and differentiation, hence the oncogenic transformation.
To explore the role of E-cadherin in the tumor progression, we have investigate the expression pattern of E-cadherin in invasive cervical carcinomas. 77 paraffin embedded specimen with FIGO staging Ia¡]N=15¡^, Ib¡]N=19¡^, Ib meta¡]N=13¡^ IIa¡]N=17¡^, IIb¡]N=13¡^were included in immunohistochemical study, 18 surgical removed tumor tissues of Ib stage and its normal counter parts were used for semi-quantitative RT-PCR analysis. The results indicated that no significant correlation between E-cadherin expression level and tumor metasis, patient prognosis. However, E-cadherin immunostainimg intensity was significanty inverse correlated with tumor size¡]p < 0.001¡^. Notably, loss of membranes E-cadherin expression might be a significant factor that correlated with tumor metasis¡]p = 0.001,< 0.005¡^.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0828103-093840 |
| Date | 28 August 2003 |
| Creators | Pan, Lin-Lin |
| Contributors | none, none, none |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0828103-093840 |
| Rights | unrestricted, Copyright information available at source archive |
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