N,N'-methylenebisacrylamide (MBA) was studied because of its effectiveness in inducing heritable translocations in germ cells of male mice. The health impact of translocations was studied through anatomical analysis of the progeny of semisterile translocation carriers. As expected, the semisterility of translocation carriers resulted primarily from embryonic death during periimplantation stages due to unbalanced chromosome sperm segregants. Among conceptuses that survived to mid- and late-gestation stages, there was an increased incidence of developmental anomalies including fetal death and phenotypic defects. These abnormalities are associated with unbalanced chromosome complements that allow survival to the later stages of development.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc500402 |
| Date | 05 1900 |
| Creators | Kile, Joanna L. (Joanna Le) |
| Contributors | White, Olivia Masih, O'Donovan, Gerard A. |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | vi, 87 leaves: ill., Text |
| Rights | Public, Kile, Joanna L. (Joanna Le), Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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