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Peripheral blood mononuclear cells as non-invasive diagnostic indicators of stress-associated neural states

Includes abstract. / Includes bibliographical references (leaves 155-181). / Researchers have demonstrated the ability to predict psychopathological states from human peripheral immune tissure transcriptional profiles, using microarrays. Although evidence in support of such an approach as a viable diagnostic avenue within psychiatric settings is accumulating, it remains to be demonstrated, in an animal model, that transcriptional changes in peripheral tissue targets are paralleled by specific gene expression changes in neural tissues.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/4347
Date January 2008
CreatorsVan Heerden, Johannes Hendrik
ContributorsIlling, Nicola, Stein, Dan
PublisherUniversity of Cape Town, Faculty of Science, Department of Molecular and Cell Biology
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeMaster Thesis, Masters, MSc
Formatapplication/pdf

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