A fractal stochastic point process (FSPP) is used to model molecular evolution in agreement with the relationship between the variance and mean numbers of synonymous and nonsynonymous substitutions in mammals. Like other episodic models such as the doubly stochastic Poisson process, this model accounts for the large variances observed in amino acid substitution rates, but unlike other models, it also accounts for the results of Ohta's (1995) analysis of synonymous and nonsynonymous substitutions in mammalian genes. That analysis yields a power-law increase in the index of dispersion and an inverse power-law decrease in the coefficient of variation with the mean number of substitutions, as predicted by the FSPP model but not by the doubly stochastic Poisson model. This result is compatible with the selection theory of evolution and the nearly-neutral theory of evolution.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc277827 |
| Date | 05 1900 |
| Creators | Bickel, David R. (David Robert) |
| Contributors | West, Bruce J., Grigolini, Paolo, Deering, William D., Kowalski, Jacek M. |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | vi, 82 leaves: ill., Text |
| Rights | Public, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved., Bickel, David R. (David Robert) |
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