Autism spectrum disorders are best understood as a complex set of symptoms that impact social, communication, and behavioral skills. Autistic brains have abnormalities in the anatomy, neural architecture, cytoarchitecture, and neurotransmitter systems (Bharath et al., 2019; Dicarlo & Wallace, 2022; Fatemi et al., 2012; Friedman et al., 2006; Karvat & Kimchi, 2014; Xu et al., 2020). This unique neurology may partially explain why motor impairments are so widespread in this population. Motor impairments are present in up to 88% of autistic people, emerging in early life and persisting into adulthood (Kangarani-Farahani et al., 2023; Liu et al., 2014). These deficits exert a cascading impact, contributing to impairments in daily living skills (Miller et al., 2024; Ozboke et al., 2021; Travers et al., 2022). Creating motor phenotypes that describe how a person’s physiology relates to their unique neurology may help with developing more effective interventions. This program investigates the correlation between biomarkers and psychomotor measures in autistic children. From there, an adjunct intervention is deployed to improve neuromodulation while engaging in motor learning. The goal is to move the field of occupational therapy towards a more precise and effective delivery model in order to achieve greater gains with less dosing of therapy.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/49170 |
| Date | 23 August 2024 |
| Creators | Alaniz, Michele L. |
| Contributors | Telesmanic, Lauren |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
| Rights | Attribution-NoDerivatives 4.0 International, http://creativecommons.org/licenses/by-nd/4.0/ |
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