DNA is a remarkable material that is both an inspiration for polymer nanotechnology and a versatile building block for assembling well-defined nanostructures. To create polymeric materials that would be useful in nanotechnology, we synthesized block copolymers containing thymine and diamidopyridine side chains. These DNA-mimetic polymers self-assembled into spherical aggregates in solution, held together by hydrogen bonding interactions. We have reported the first example of a block copolymer micellar aggregate that is capable of selective recognition of small-molecule guests, with concomitant changes in its aggregation behavior. / In the field of DNA-mediated materials, the ordering of gold nanoparticle (AuNP) arrays can be hindered by the lability of AuNP-DNA linkages. In the search of an indefinitely stable AuNP-DNA linkage, three dendritic thiol-terminated DNA strands were synthesized, and were bound to AuNPs. A preliminary AuNP-DNA linkage lability study showed potential in forming nonlabile AuNP-DNA linkages through the use of dendritic thiol-modified DNA.
Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.112640 |
Date | January 2007 |
Creators | Ishihara, Yoshihiro. |
Publisher | McGill University |
Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
Language | English |
Detected Language | English |
Type | Electronic Thesis or Dissertation |
Format | application/pdf |
Coverage | Master of Science (Department of Chemistry.) |
Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
Relation | alephsysno: 002712525, proquestno: AAIMR51286, Theses scanned by UMI/ProQuest. |
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