A theoretical part of the diploma thesis describes solubility, classification of solubility and ways of influencing of solubility, and it gives a detailed summary of naproxen as the drug further used and evaluated in in vitro experiments for drug release. An experimental section is focused to in vitro release of naproxen from nanofibre membranes produced by electrospinning with regard to the possibility of the use of layering. At both layered and non-layered nanofibre membranes of three different naproxen concentrations (e.g. 5%, 15% and 30% by weight) the drug release amounts within 5 minutes were from 10 to 90 percent of total amounts. An overal percentage of naproxen released in 60 minutes was always about 100 % of the total drug loaded in the nanomembranes. The nanofibre membranes layered with the glycerol and propylene glycol were of the same profiles as with non-layered membranes.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:325229 |
| Date | January 2013 |
| Creators | Urbanová, Martina |
| Contributors | Doležal, Pavel, Berka, Pavel |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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