In the present study, for estimating the Central Asia contribution to the Anatolia, nine Alu insertion polymorphisms (ACE, PV92, FXIIIB, APO, A25, B65, TPA25, D1, HS4.32 ) in 100 individuals from Anatolia were examined. Alu insertion frequency for these loci were calculated as 0,410 / 0,220 / 0,579 / 0,963 / 0,067 / 0,667 / 0,390 / 0,427 / and 0,637 respectively and they were found to be in Hardy-Weinberg equilibrium (p< / 0,05). Observed insertion frequencies of each loci were compared with those of the previous observations (Dinç / , 2003 / Comas et al., 2004) and it was found that the present study results were not different than those obtained by Comas et al. (2004). Thus, these two data were pooled (N = 143) and used to examine genetic relationships between populations from Eurasia and Africa.
Pairwise Fst statistics indicated that there is higher genetic similarity between Anatolia and all of the Balkans and some of the Caucasian populations. Neighbor Joining (NJ) tree based on Reynold&rsquo / s genetic distances and Principal Component Analysis (PCA) both grouped the Anatolian populations with Balkans and some of the Caucasian populations and show clear differentiation of Asian populations from the Anatolian population.
The relative genetic contribution of Central Asian genes to the current Anatolian gene pool was quantified using Admix analysis, considering for comparison populations of Balkans (Greek, Romania, Albania and Hungarian) and Central Asia (Uighur, Uzbeks, Tajicks, Kazaks, Kyrgyzes, Dungans). Estimates suggest roughly 28 % contribution from Asia to Anatolia in concordance with the previous estimation (Benedetto et al., 2001).
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12606573/index.pdf |
| Date | 01 September 2005 |
| Creators | Sekeryapan, Ceran |
| Contributors | Togan, Inci |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | M.S. Thesis |
| Format | text/pdf |
| Rights | To liberate the content for public access |
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