Indiana University-Purdue University Indianapolis (IUPUI) / Opioid misuse and addiction has been widely identified as a public health
problem, contributing substantially to the nation’s morbidity and mortality. Over the
past two decades, misuse of prescription opioids pain relievers has substantially
increased; heroin use has resurged; and, more recently, abuse of high-potency synthetic
opioids such as fentanyl have fueled the epidemic. Nearly 12 million Americans (or
4.4%) aged 12 and older misused some type of opioid (prescribed or illegal) in the past
year. Furthermore, the percentage of substance use treatment admissions attributable
to opioids nearly doubled in the U.S., from 20.8% in 2000 to 40.5% in 2015.
The purpose of this dissertation research was to investigate associations
between prescription pain reliever use and subsequent negative health outcomes,
including opioid misuse or addiction, and neonatal abstinence syndrome. This research
focused on three specific aims:
Specific Aim #1: Examine heroin use among Indiana’s substance use treatment
population to measure the extent, trends, and patterns of use, as well as to assess the
relationship between prescription opioids and subsequent heroin use;
Specific Aim #2: Analyze 2014 INSPECT (Indiana’s prescription drug monitoring
program) data to identify factors that increase patients’ likelihood to engage in opioidrelated
risk behaviors; and Specific Aim #3: Review U.S. trends in neonatal abstinence syndrome (NAS)
incidence from 2008-2014, measure regional variability, and identify personal and
environmental risk factors associated with NAS. / 2020-08-09
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/17108 |
| Date | 22 May 2018 |
| Creators | Greene, Marion Siegrid |
| Contributors | Zollinger, Terrel W., Steele, Gregory K., Yiannoutsos, Constantin T., Chambers, R. Andrew, Vest, Joshua R., Wright, Eric R. |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Dissertation |
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