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New frontiers in population recording

The advent of reliable simultaneous recording of the activity of many neurons has enabled the study of interactions between neurons at a large scale: the number of observed pairwise interactions is proportional to the square of the number of recorded neurons. The dominant phenomenon in these pairwise interactions is synchronization, reflecting a system where many observed variables have in common a smaller set of latent variables. This permits the possibility that the complex signals observed in the brain might be reducible to a simpler system. We used this insight to design a better signal processing scheme for neuroprosthetics; to identify the same neurons in many recording sessions from their pairwise interactions; to show that the tuning functions of neurons in motor and premotor cortex do not reflect simple coordinate frame models; and to identify error as a dominant signal during continuous movements.

Identiferoai:union.ndltd.org:PITT/oai:PITTETD:etd-04132011-154920
Date14 April 2011
CreatorsFraser, George Williams
ContributorsAndrew B Schwartz, Peter L Strick, Maneesh Sahani, Robert E Kass, Douglas J Weber, Tai Sing Lee
PublisherUniversity of Pittsburgh
Source SetsUniversity of Pittsburgh
LanguageEnglish
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.library.pitt.edu/ETD/available/etd-04132011-154920/
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