This study is concerned with the demonstration of the immunochemical specificity of central and peripheral nervous system antigens. Early observations of occasional "neuroparalytic" accidents following immunization with rabies vaccine containing nervous tissue antigens gave rise to speculations that immunological reactions could lead to clinical disease (Stuart, 1925). In subsequent years, neurological syndromes following inoculation of various vaccines, injections of foreign serum or associated with certain infectious diseases such as measles have become increasingly recognized (Miller, Stanton and Gibbons, 1956). These hypersensitivity reactions affect various parts of the nervous system resulting in encephalitis, myelitis or neuritis. In addition, many spontaneously occurring neurological disorders such as the Guillain-Barré syndrome (Melnick, 1963) and neurological complications associated with the collagen disorders are suspected of being the result of hypersensitivity reactions (Gell and Coombs, 1964). [...]
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.118188 |
| Date | January 1965 |
| Creators | Sherwin, Allan L. |
| Contributors | Cosgrove, J. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy. (Department of Neurology & Neurosurgery.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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