Inhibited temperament is a biological risk factor for the development of social anxiety disorder. In adolescents and young adults, inhibited temperament has been associated with increased amygdala reactivity and alterations in prefrontal cortex regulation. Brain activation in children with an inhibited temperament who have yet to develop anxiety disorders has not been examined. In this study of young children, we identified neural vulnerabilities in the prefrontal cortex activation associated with preparing to view social stimuli. Further, we found that inhibited children had stronger connections within a limbic-visual processing network when preparing to view social stimuli. This is the first study to identify underlying neural vulnerabilities associated with inhibited temperament and to show that young children with this phenotype already have critical alterations in brain activation.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-11062014-114744 |
| Date | 03 December 2014 |
| Creators | Clauss, Jacqueline Alexandra |
| Contributors | Bruce McCandliss, Ron Cowan, Jennifer Blackford, Uma Rao |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-11062014-114744/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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