NEUROSCIENCE
Evaluating Multisensory Processing in the Mouse Model: Clinical and Translational Implications
Justin Kyle Siemann
Dissertation under the direction of Mark T. Wallace
Multisensory integration is the synthesis of information from the different sensory systems. Numerous investigations have evaluated multisensory function in humans and in various animal models with these studies demonstrating significant neural, behavioral and perceptual benefits conferred under multisensory conditions. In addition, emerging studies have described atypical multisensory function in clinical populations such as those with autism spectrum disorder. While a variety of animal models have been used to assess multisensory processing, there were no current behavioral tasks available for the mouse model. Here, we demonstrate the first behavioral paradigm to assess and evaluate multisensory processing in the mouse, and which show similar behavioral benefits as compared to larger animal species. In addition, we then demonstrate the first characterization of atypical multisensory behavioral function in a mouse model associated with autism spectrum disorder. Lastly, we observed that depending on the type of behavioral task implemented, mice can demonstrate vastly different behavioral responses under these multisensory conditions. Overall, we describe a series of novel studies that examine and characterize multisensory behavioral function in the mouse model system with the belief that this work may provide opportunities for further insights into the underlying neural mechanisms of multisensory function in both typical development and in autism spectrum disorder.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-12272015-153630 |
| Date | 28 December 2015 |
| Creators | Siemann, Justin Kyle |
| Contributors | Mark Wallace, Jeremy Veenstra-VanderWeele, James Bodfish, Stephen Camarata, Beth Malow |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-12272015-153630/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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