The hippocampus is a medial temporal lobe structure involved in learning and memory. Several magnetic resonance imaging methods exist to investigate hippocampal structure and function in vivo. Some of these methods provide information about the anterior and posterior hippocampus while other methods can examine its subfields. In this study, we applied several imaging techniques to study hippocampal structure, blood volume (CBV), and blood flow (CBF) in early psychosis and chronic schizophrenia. We characterized CBV gradients in the hippocampus and its subfields and found increased anterior CA1 CBV in chronic schizophrenia. Hippocampal CBF was normal in the same cohort of chronic, medicated patients. When we studied patients in early psychosis, we found no hippocampal volume and CBF differences. However, we found an inverse relationship between hippocampal volume and CBF and a trend towards increased anterior hippocampal CBV. This study provides comprehensive, multi-modal imaging to characterize hippocampal structural and functional alternations in a clinical population.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-08132015-191444 |
| Date | 17 August 2015 |
| Creators | Talati, Pratik |
| Contributors | Stephan H.W. Heckers, MD, MSc, Manus J Donahue, PhD, Bruce D. Carter, PhD, Brandon A. Ally, PhD |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-08132015-191444/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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