Combination antiretroviral therapy (cART)-treated people living with human immunodeficiency virus (HIV) (PLWH) face an increased risk of atherosclerosis associated cardiovascular disease (ASCVD) even after controlling for traditional and non-traditional risk factors (Freiberg et al. 2013). Persistent HIV-associated immune activation (monocyte and T-cell activation) is believed to contribute to heightened complications of ASCVD including, myocardial infarction (MI), and stroke in PLWH (Hsue et al. 2009; Kearns et al. 2017). Specifically, systemic immune activation predisposes PLWH to arterial inflammation (characterized by increased arterial macrophage infiltration), and accelerated atherogenesis (Lo et al. 2010; Burdo, Lo, et al. 2011; Fitch et al. 2013; Subramanian et al. 2012; Tawakol et al. 2016). Accelerated atherogenesis has even been noted among elite controllers, or PLWH who maintain undetectable virus levels in the absence of cART (Pereyra et al. 2012), suggesting that the proc / Biomedical Sciences
| Identifer | oai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/1586 |
| Date | January 2018 |
| Creators | Kearns, Alison Catherine |
| Contributors | Qin, Xuebin, Burdo, Tricia Helen, Wang, Hong, 1956 September 19-, Rappaport, Jay, Gordon, Jennifer, Wigdahl, Brian |
| Publisher | Temple University. Libraries |
| Source Sets | Temple University |
| Language | English |
| Detected Language | English |
| Type | Thesis/Dissertation, Text |
| Format | 122 pages |
| Rights | IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available., http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | http://dx.doi.org/10.34944/dspace/1568, Theses and Dissertations |
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