Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting over five million people in the US alone. Causes for the most common sporadic form of the disease are still obscure and no therapeutic approach is available to halt the progression of AD. Subjects whose mothers were affected by sporadic AD are three times more susceptible to develop the disease later in life compared to subject from sporadic AD fathers. However, the mechanisms of maternal transmissibility for sporadic AD are unknown. Lifestyle and nutrition are important risk factors for sporadic AD. Direct exposure to saturated fats and cholesterol is positively correlated to AD development later in life. We hypothesized that maternal exposure to high-fat diet throughout gestation would affect AD susceptibility in the offspring later in life. To tackle this biological question, triple transgenic (3xTg) dams carrying human APP (KM670/671NL), PSEN1 (M146V) and MAPT (P301L) mutations together with wild type da / Biomedical Sciences
| Identifer | oai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/2788 |
| Date | January 2019 |
| Creators | DI MECO, ANTONIO |
| Contributors | Praticò, Domenico, Abood, Mary Ellen, 1958-, Issa, Jean-Pierre, Rawls, Scott M., Kishore, Raj |
| Publisher | Temple University. Libraries |
| Source Sets | Temple University |
| Language | English |
| Detected Language | English |
| Type | Thesis/Dissertation, Text |
| Format | 108 pages |
| Rights | IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available., http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | http://dx.doi.org/10.34944/dspace/2770, Theses and Dissertations |
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