Aging increases the risk of both cardiovascular disease and dementia. Incidence of dementia such as Alzheimer’s Disease increases with aging. Dementia and cardiovascular diseases have not been associated, but ongoing research points to possible correlation between them.
The aim of this study was to investigate whether there is a causal relationship between aging, neuroinflammation, cerebral microbleeds, and vascular dementia in a wild-type C57BL/6 mouse model. Microbleeds were found to be worse in aged mice compared to young adult mice by using Prussian Blue staining histology.[1] Immunohistochemistry assays on microglia were used to determine inflammation status. Novel Object Recognition (NOR) test and locomotor activity tests were used to assess animal behavior and cognitive ability. The current study aimed at eventually developing a possible treatment for cognitive ability decline and cardiovascular damage by targeting inflammation. This study also suggested a possible mechanism for the cause of cerebral microbleeds. / 2024-05-23T00:00:00Z
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/44476 |
| Date | 23 May 2022 |
| Creators | Xie, Songlin |
| Contributors | Morgan, Kathleen G. |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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