Kleine Levin Syndrome (KLS) is a hypersomniac disease of episodic nature that affects only 1-5 per million individuals globally. In addition to extensive periods of sleep (> 20 hours) patients experience a wide range of symptoms during an episode, which occur approximately 1-12 times a year with a median of 10 days. The etiology and pathophysiology of the disease is unknown. Diagnostic criteria (The International Classification of Sleep disorders, third addition) rely solemnly on symptomatic characteristics. Misdiagnosis is unfortunately common. The potential of using hypocretin-1, amyloid-beta/tau and the IgG index in the CSF as potential disease biomarkers was investigated. Measurements were taken during the asymptomatic and/or symptomatic phase of the disease. All values were within the normal range. Lower hypocretin-1 values were observed in the asymptomatic phase compared to the symptomatic phase in two of the three patients, although not statistically significant.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-357303 |
| Date | January 2018 |
| Creators | Euler, Nora |
| Publisher | Uppsala universitet, Institutionen för biologisk grundutbildning |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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