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M1 macrophages promote morphological changes and NF-KAPPA B nuclear translocation in prostate epithelial cells

In this study, we sought to define an underlying molecular mechanism of how inflammation induces cancer initiation. Cancer-associated inflammation is marked by the presence of inflammatory cells and mediators including cytokines, chemokines, and reactive oxygen species. There is a growing body of evidence establishing the link between chronic inflammation and cancer. Twenty percent of cancers have been linked to chronic infections. For instance, bacterial and viral infections induce inflammation which is a known risk factor for cancer. During inflammation, Ml macrophages' production of pro-inflammatory cytokines and reactive oxygen species (ROS) drives their function as anti-microbial. Likewise, the transcription factor nuclear factor kappa B (NF-KB) is known to induce a variety of stimulators, including ROS, to contribute to the inflammatory process. Therefore, we sought to explore the relationship between Ml macrophages and NF-KB, suggesting that Ml macrophage mediates cancer initiation via a NF-KB-dependent pathway, which collectively contributes to a metastatic phenotype.

Identiferoai:union.ndltd.org:auctr.edu/oai:digitalcommons.auctr.edu:dissertations-4721
Date01 July 2016
CreatorsDavis, Ahriea
PublisherDigitalCommons@Robert W. Woodruff Library, Atlanta University Center
Source SetsAtlanta University Center
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceETD Collection for AUC Robert W. Woodruff Library

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