Late-onset Alzheimer disease (LOAD) is a complex neurodegenerative disorder with a strong genetic component. APOE is a well-established risk gene for LOAD, and several other genes have also been identified. However, at least half of the genetic component for LOAD remains unexplained. Genetic heterogeneity complicates identifying the remaining risk genes. To overcome this problem the objective of my thesis work was to study the Amish communities of Ohio and Indiana, a genetically isolated founder population to identify a novel LOAD risk gene(s). I first performed quality control procedures on a set of genome-wide single nucleotide polymorphisms (SNPs) genotyped in the Amish. I then performed genome-wide linkage and association analyses in the cleaned dataset. Lastly, I performed a candidate gene sequence analysis.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-11292012-074432 |
| Date | 07 December 2012 |
| Creators | Cummings, Anna Christine |
| Contributors | Jonathan L. Haines, Dana C. Crawford, William K. Scott, Michael G. Tramontana, Bingshan Li |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-11292012-074432/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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