Precipitation polymerization is a unique method that produces narrow-disperse, uniform polymer particles with clean surfaces. In this research, internally structured poly(divinylbenzene-co-chloromethylstyrene) polymer microspheres were prepared by thermal imprinting precipitation polymerization. The influence of thermal profiles and the monomer/crosslinker feed ratio on the resulting core-shell microspheres were explored by optical and transmission electron microscopy, and potential route to extend this technique to other polymer system was discussed. Further surface functionalization of this type of particles was demonstrated by substitution of chlorine with cysteine, a good and hydrophilic nucleophile. Narrow-disperse, hydrophilic particles may in future serve as components of synthetic extracellular matrices used in exploring cell-matrix interactions in a 3D context. / Thesis / Master of Science (MSc)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/18199 |
| Date | 11 1900 |
| Creators | Zhao, Yuqing |
| Contributors | Stover, Harald, Chemistry |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
| Type | Thesis |
Page generated in 0.0169 seconds