Type 2 diabetes mellitus (T2DM) is often characterized with hyperglycemia, delayed gastric emptying time and a blunted response of gut hormones during feeding that may modulate hunger and satiety. We hypothesized that poor diabetes control is associated with greater hunger suppression, satiation and satiety than good control. We studied 9 T2DM men, after an overnight fast and in response to a 689 kcal mixed meal, twice with or without oral antihyperglycemic agents in a crossover design. Untreated, subjects had higher fasting and postprandial glucose, showed prolonged gastric emptying time and higher thermic effect of food; all factors associated with hunger suppression. Treated, glycemia decreased by 24% and postprandially GLP-1 and PYY3-36 , peptides associated with hunger suppression, were higher than without medication. Thus, no differences were observed in satiation scores between studies. However food intake from a buffet offered 5 hours post meal, an index of satiety, related to hunger scores only in the study with medication.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.112543 |
| Date | January 2008 |
| Creators | Mourad, Carine J. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Dietetics and Human Nutrition.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002770481, proquestno: AAIMR51311, Theses scanned by UMI/ProQuest. |
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