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Propofol: analytical techniques and applied pharmacokinetics.

by Wong Kwok Kong. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 163-184). / Abstract --- p.2 / Preface / Acknowledgements --- p.6 / List of abbreviations --- p.7 / List of Tables --- p.8 / List of Figures --- p.13 / CONTENTS --- p.16 / Chapter Chapter One: --- Introduction --- p.23 / Chapter Chapter Two: --- Review of pharmacology of propofol --- p.26 / Chapter 1: --- Chemistry structure-Activity relationship --- p.27 / Chapter 2: --- Pharmacokinetics --- p.28 / Chapter 2.1: --- Distribution --- p.29 / Chapter 2.2: --- Elimination --- p.30 / Chapter 2.3: --- "Effects of age, sex, and hepatic and renal disease on the pharmacokinetics of propofol" --- p.35 / Chapter 2.3.1: --- Effects of age / Chapter 2.3.2: --- Effects of sex / Chapter 2.3.3: --- Effects of renal and hepatic disease / Chapter 3: --- Pharmacodynamic --- p.38 / Chapter 3.1: --- Anaesthetic concentrations --- p.38 / Chapter 3.2: --- Recovery characteristics --- p.39 / Chapter 3.3: --- Effects on the cardiovascular system --- p.40 / Chapter 3.4: --- Effects on the respiratory system --- p.43 / Chapter 3.5: --- Effects on cerebral blood flow and intracranial pressure --- p.44 / Chapter 3.6: --- Other effects --- p.45 / Chapter 3.6.1: --- Effects on liver function / Chapter 3.6.2: --- Effects on renal function / Chapter 3.6.3: --- Effects on coagulation / Chapter 3.6.4: --- Effects on adrenal steroidgenesis / Chapter 3.7: --- Side effects --- p.47 / Chapter 3.7.1: --- Pain on injection / Chapter 3.7.2: --- Excitatory & respiratory / Chapter 3.7.3: --- Nausea and vomiting / Chapter 3.7.4: --- Bradycardia / Chapter 3.7.5: --- Anaphylaxes / Chapter 4: --- Clinical use --- p.51 / Chapter 4.1: --- Anaesthesia induction --- p.52 / Chapter 4.2: --- Anaesthesia maintenance --- p.53 / Chapter 4.3: --- Use in sedation --- p.57 / Chapter Chapter Three : --- Analytical Technique:Propofol content analysis --- p.58 / Chapter 1: --- Introduction high-pressure liquid chromatography --- p.58 / Chapter 2: --- Methods of propofol content analysis --- p.61 / Chapter 2.1: --- Reagents and solutions --- p.61 / Chapter 2.1.1: --- Sodium dihydrogen phosphate / Chapter 2.1.2: --- Cyclohexane / Chapter 2.1.3: --- Tetramethylammonium Hydroxide Solution / Chapter 2.1.4: --- Acetonitrile / Chapter 2.1.5: --- Acetic acid / Chapter 2.2: --- Standard solution --- p.62 / Chapter 2.2.1: --- Propofol standards / Chapter 2.2.2: --- Internal standard / Chapter 2.2.3: --- Control standard / Chapter 2.3: --- Mobile phase --- p.63 / Chapter 2.4: --- High-pressure liquid chromatography --- p.63 / Chapter 2.5: --- Quantification --- p.64 / Chapter 2.6: --- Procedure --- p.67 / Chapter 2.7: --- Throughput --- p.69 / Chapter 2.7.1: --- Fist working day / Chapter 2.7.2: --- Second working day / Chapter 2.7.3: --- Third working day / Chapter 2.7.4: --- Fourth working day / Chapter 2.7.5: --- Fifth working day / Chapter 3: --- Results of propofol content analysis --- p.71 / Chapter 3.1: --- Calibration standard of propofol (Linearity) --- p.71 / Chapter 3.2: --- Control standard of propofol --- p.74 / Chapter 3.2.1: --- Reproducibility / Chapter 3.2.2: --- Recovery / Chapter 3.2.3: --- Stability / Chapter 4: --- Discussion of propofol content analysis --- p.80 / Chapter 4.1: --- Calibration standard of propofol --- p.80 / Chapter 4.2: --- Precision and accuracy of analytical method --- p.86 / Chapter 4.3: --- Extraction efficiency of analytical method --- p.87 / Chapter 4.4: --- Stability of analytical met --- p.89 / Chapter Chapter Four: --- Analytical technique: Protein binding of propofol --- p.91 / Chapter 1: --- Introduction protein binding of propofol --- p.91 / Chapter 1.1: --- Ultrafiltration --- p.92 / Chapter 1.2: --- Equilibrium dialysis --- p.92 / Chapter 2: --- Methods of protein binding of propofol --- p.94 / Chapter 2.1: --- Material & Solution --- p.94 / Chapter 2.1.1: --- Dialysis buffer / Chapter 2.1.2: --- Molecularporous Dialysis Membrane / Chapter 2.2: --- Equilibrium dialysis --- p.96 / Chapter 2.3: --- Determine the optimum dialysis time to reach equilibrium --- p.97 / Chapter 2.3.1: --- Material / Chapter 2.3.2: --- Procedure / Chapter 3: --- Results of protein binding of propofol --- p.99 / Chapter 3.1: --- Results for optimum dialysis time to reach equilibrium --- p.99 / Chapter 3.2: --- Results for reproducibility --- p.101 / Chapter 3.2.1: --- Intraassay coefficient of variation (One analysis day) of propofol in plasma and in protein binding / Chapter 3.2.2: --- Interassay coefficient of variation (Seven analysis days) of propofol in plasma and in protein binding / Chapter 3.3: --- Results for recovery of propofol in plasma and in protein binding --- p.106 / Chapter 3.3.1: --- Recovery of propofol (unheated samples) / Chapter 3.3.2: --- Recovery of propofol (samples heated at 37°C) / Chapter 3.3.3: --- Recovery of propofol (after dialysis at 37°C) / Chapter 3.4: --- Results for stability of propofol in plasma --- p.112 / Chapter 4: --- Discussions of protein binding of propofol --- p.114 / Chapter 4.1: --- Optimum dialysis time to reach equilibrium --- p.114 / Chapter 4.2: --- Discussion for Intraassay & Interassay coefficient of variation of propofolin plasma and in protein binding --- p.114 / Chapter 4.3: --- Recovery of propofol in plasma and in protein binding --- p.116 / Chapter 4.4: --- Discussion for stability of propofolin plasma --- p.118 / Chapter Chapter Five: --- Clinical application of pharmacokinetic studies --- p.119 / Chapter 1: --- Introduction pharmacokinetic model controlled infusion / Chapter 1.1: --- Theoretical basis --- p.119 / Chapter 1.2: --- Use of computer & appropriate pump --- p.123 / Chapter 2: --- Results of propofol pharmacokinetic studies --- p.124 / Chapter 2.1: --- Sample prepare --- p.124 / Chapter 2.2: --- Computer control infusion of propofol according to pharmacokinetic model --- p.126 / Chapter 2.3: --- Comparison of measured and predicted blood concentrations of propofol --- p.129 / Chapter 2.4: --- Test the new paediatric pharmacokinetic model (the revised paediatric rate constants) --- p.136 / Chapter 3: --- Discussion of propofol pharmacokinetics studies: Infusion for Chinese children --- p.141 / Chapter Chapter Six: --- Clinical application on protein binding studies --- p.143 / Chapter 1: --- Plasma proteins and drug binding --- p.143 / Chapter 2: --- Methods of propofol protein binding studies --- p.145 / Chapter 2.1: --- Blood sample acquisition --- p.145 / Chapter 2.2: --- Population characteristics --- p.145 / Chapter 2.3: --- Methods of protein binding assay --- p.145 / Chapter 3: --- Results of propofol protein binding --- p.146 / Chapter 4: --- Discussion of propofol protein binding --- p.153 / Chapter 4.1: --- Protein binding of propofol in Chinese children --- p.154 / Chapter 4.2: --- Protein binding of propofol in pregnant women & neonate --- p.155 / Chapter Chapter Seven: --- Conclusions --- p.158 / References --- p.163 / Appendix --- p.180

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_320696
Date January 1995
ContributorsWong, Kwok Kong., Chinese University of Hong Kong Graduate School. Division of Surgical Sciences.
PublisherChinese University of Hong Kong
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, 184 leaves : ill. ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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