Thesis advisor: Larry W. McLaughlin / Hydration in the minor groove of B-form DNA influences the stability and conformation of duplex DNA. An analogue nucleoside that attempts to mimic the N3-hydrated adenine was designed and synthesized. Obtaining the modified adenine was a significant synthetic effort. The attempted incorporation of the new analogue in a DNA strand yielded inconclusive results, and further tests are ongoing. The incorporation of the new modified purine in a DNA duplex may be useful for a better understanding of the hydration of B-form DNA. / Thesis (MS) — Boston College, 2012. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.
| Identifer | oai:union.ndltd.org:BOSTON/oai:dlib.bc.edu:bc-ir_101229 |
| Date | January 2012 |
| Creators | Carlson, Alena |
| Publisher | Boston College |
| Source Sets | Boston College |
| Language | English |
| Detected Language | English |
| Type | Text, thesis |
| Format | electronic, application/pdf |
| Rights | Copyright is held by the author, with all rights reserved, unless otherwise noted. |
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