Song Hong. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (leaves ). / Abstracts in English and Chinese; questionnaire in Chinese. / Abstract (English) --- p.i / Abstract (Chinese) --- p.iv / Acknowledgments --- p.vi / Table of Contents --- p.vii / List of tables --- p.x / Chapter Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Printing industry and organic solvents exposure --- p.1 / Chapter 1.2 --- Risk of low level exposures to organic solvents --- p.2 / Chapter 1.3 --- Using neurobehavioral methods to study the subclinical effects --- p.3 / Chapter Chapter 2 --- Literature review --- p.4 / Chapter 2.1 --- Organic solvents and neurobehavioral impairment --- p.4 / Chapter 2.2 --- Methodology of Neurobehavioral Test --- p.6 / Chapter 2.2.1 --- Criteria for selecting test battery --- p.7 / Chapter 2.2.2 --- Standardization of neurobehavioral test battery --- p.8 / Chapter 2.2.3 --- Reliability and validity --- p.9 / Chapter 2.2.4 --- Confounding factors of neurobehavioral test --- p.10 / Chapter 2.3 --- Neurobehavioral effects of different levels of solvent exposures --- p.12 / Chapter 2.3.1 --- Positive results in field studies --- p.12 / Chapter 2.3.2 --- Negative results in field studies --- p.17 / Chapter 2.3.3 --- Dose-response relationship in the field studies --- p.18 / Chapter 2.3.4 --- To separate acute and chronic effects --- p.20 / Chapter 2.3.5 --- The long-term effects of solvent exposure --- p.21 / Chapter 2.4 --- Limitations of these studies --- p.23 / Chapter 2.5 --- Summary --- p.26 / Chapter Chapter 3 --- Aims and Objectives --- p.31 / Chapter 3.1 --- Aims of the present research --- p.31 / Chapter 3.2 --- Position of this study cm this research domain --- p.32 / Chapter Chapter 4 --- Subjects and Method --- p.33 / Chapter 4.1 --- Study design --- p.33 / Chapter 4.2 --- Study population and sampling --- p.33 / Chapter 4.2.1 --- Participation --- p.33 / Chapter 4.2.2 --- Exposed group --- p.34 / Chapter 4.2.3 --- Reference group --- p.34 / Chapter 4.2.4 --- Sample size estimation --- p.34 / Chapter 4.3 --- Data collection --- p.36 / Chapter 4.3.1 --- Exposure assessment --- p.36 / Chapter 4.3.1.1 --- Air sample measurements --- p.36 / Chapter 4.3.1.2 --- Biological monitoring --- p.38 / Chapter 4.3.2. --- Medical assessment --- p.38 / Chapter 4.3.2.1 --- Pre-test questionnaire --- p.39 / Chapter 4.3.2.2 --- Neurobehavioral assessment --- p.39 / Chapter 4.4 --- Data Analysis --- p.43 / Chapter 4.4.1 --- Data Processing --- p.43 / Chapter 4.4.2 --- Statistical analysis --- p.44 / Chapter 4.4.2.1 --- Descriptive analysis --- p.44 / Chapter 4.4.2.2 --- Identifying the main confounding factories --- p.44 / Chapter 4.4.2.3 --- Comparing the tests score adjusted for confounding --- p.45 / Chapter 4.4.2.4 --- Dose-response analysis --- p.45 / Chapter Chapter 5 --- Results --- p.47 / Chapter 5.1 --- Demographic characteristics of the subjects --- p.47 / Chapter 5.2 --- Comparison of the basic characteristics between the exposed group and the reference group --- p.48 / Chapter 5.3 --- Comparison of the symptoms between the exposed group and the reference group --- p.49 / Chapter 5.4 --- Comparison of the scores of neurobehavioral tests between the exposed group and the reference group --- p.51 / Chapter 5.5 --- Identifying potential confounding of neurobehavioral test --- p.51 / Chapter 5.5.1 --- Main confounding factors of NCTB test on performance tests --- p.51 / Chapter 5.5.2 --- Main confounding factors of Profile of Mood States --- p.54 / Chapter 5.6 --- Groups comparison of the neurobehavioral effects --- p.57 / Chapter 5.6.1 --- Comparison of the adjusted mean scores between the exposed group and the reference group --- p.57 / Chapter 5.6.2 --- Groups comparison of the adjusted tests score in Factories C and G respectively --- p.58 / Chapter 5.7 --- Exposure assessment --- p.61 / Chapter 5.7.1 --- Air sampling results of the printing factories --- p.62 / Chapter 5.7.2 --- Relationship between results of active and passive sampling systems --- p.63 / Chapter 5.7.3 --- Biological monitoring --- p.63 / Chapter 5.8 --- Dose-response relationship --- p.65 / Chapter Chapter 6 --- Discussion --- p.69 / Chapter 6.1 --- Findings of this study --- p.69 / Chapter 6.1.1 --- Subjective symptoms --- p.69 / Chapter 6.1.2 --- Neurobehavioral effects --- p.70 / Chapter 6.1.3 --- Exposure intensity --- p.72 / Chapter 6.1.4. --- Dose-response relationship --- p.75 / Chapter 6.2 --- Applications of the study results --- p.76 / Chapter 6.2.1 --- The need for prevention measures --- p.77 / Chapter 6.2.2 --- Contributing to re-setting of OELs --- p.77 / Chapter 6.2.3. --- The evidence on neurotoxicology --- p.78 / Chapter 6.3 --- Limitations of the study --- p.79 / Chapter 6.3.1. --- Possibility of bias --- p.79 / Chapter 6.3.2. --- Lack of historical hygiene measurement data --- p.80 / Chapter 6.3.3. --- Influence of workshift --- p.81 / Chapter 6.3.4. --- Combined exposures to noise and organic solvents --- p.82 / Chapter 6.4 --- Conclusion --- p.83 / Appendices --- p.84 / Appendix 1 --- p.84 / Appendix 2 --- p.97 / Appendix 3 --- p.102 / Appendix 4 --- p.103 / Appendix 5 The Administration of The WHO-NCTB Tests --- p.114 / Test 1 Profile of Mood States Test --- p.115 / Test 2. Simple Reaction Time Test --- p.116 / Test 3. Digit Span Test Test --- p.119 / Test 4. Santa Ana Test --- p.120 / Test 5. Digit Symbol Test --- p.122 / Test 6. Benton Visual Retention Test --- p.123 / Test 7. Pursuit Aiming Test --- p.125 / Appendix 6 --- p.126 / Reference List --- p.127
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_323023 |
| Date | January 2000 |
| Contributors | Song, Hong., Chinese University of Hong Kong Graduate School. Division of Medical Sciences. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, x, 135 leaves : ill. (some col.) ; 30 cm. |
| Coverage | Hong Kong, Hong Kong |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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