The Missouri Poultry Cohort is a historical cohort investigation of mortality among workers highly exposed to the poultry oncogenic viruses which are suspected cancer causing agents in humans. Workers were also exposed to fumes from PVC-wrapping activities that contain chemicals known or suspected to produce cancer in humans The cohort mortality pattern is similar to what is often observed in occupational studies, where the healthy worker effect takes place As a group, cancer mortality also does not shows excess. However, cancer of bronchus, trachea & lung and cancer of kidney present statistically significant excess when the plants are introduced in the analysis. A positive dose response relationship was found for cancer of bronchus, trachea & lung, and cancer of kidney by means of latency and duration of employment analysis. In lesser extent, some cancers of the lymphopoietic system are also excessive: Lymphosarcoma & Reticulosarcoma, Leukemia & Aleukemia, and Cancer of All Other Lymphopoietic Tissues. Several other cancers also are excessive as cancer of stomach, cancer of large intestine, cancer of pancreas, cancer of bladder, cancer of cervix, cancer of thyroid, and cancer of central nervous system The cohort experienced an excessive mortality of Non-Malignant Respiratory Diseases. From the external causes of death, Motor Vehicle Accidents and Homicides & Other External Causes are also in excess. All other causes of death, covering a broad spectrum of diseases, also presents excess By taking race into consideration in the PMR analysis it was identified that the cancer of bronchus, trachea & lung excess is greater in the nonwhite female group. In lesser extent, it also suggests nonwhite-male excess of cancer of bronchus, trachea & lung The major limitations of this investigation are the relative short time of follow-up, the potential role of confounding factors that were not taken into account in the assessment of risk, and the small number of observed deaths in the cancers of interest The major strengths are the high intensity of chicken oncogenic viruses exposure in a homogeneous population, the assessment of missing information in the SMR analysis, and the consistency of the positive cancer results of this investigation with previous findings from occupational investigations in the Chicken Slaughtering/Processing Industry / acase@tulane.edu
| Identifer | oai:union.ndltd.org:TULANE/oai:http://digitallibrary.tulane.edu/:tulane_25806 |
| Date | January 1998 |
| Contributors | Netto, Guilherme Franco (Author), Johnson, Eric S (Thesis advisor) |
| Publisher | Tulane University |
| Source Sets | Tulane University |
| Language | English |
| Detected Language | English |
| Rights | Access requires a license to the Dissertations and Theses (ProQuest) database., Copyright is in accordance with U.S. Copyright law |
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