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Chemically Active Odorants as Olfactory Probes

The initial step in odor recognition by the nose is the binding of odorant molecules to receptor sites embedded in the dendritic membranes of olfactory receptor cells. Despite considerable interest and experimentation into the nature of these receptor sites, little is known of their specificity to different types of odorant molecules. This lack of knowledge partially stems from the fact that the nature of receptor proteins is most effectively studied when specific and irreversible inhibitors are available for use as chemical probes, yet no such agents have been discovered for use in the olfactory system. A series of alkylating agents and other chemically active odorants were tested to determine whether they might react with specific odorant receptors and modify olfactory responses. Electroolfactogram (EOG) recordings were obtained before, during, and after treatment of the olfactory mucosae of grass frogs (Rana pipiens) with a chemically active odorant.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc331058
Date05 1900
CreatorsCriswell, Darrell W. (Darrell Wayne)
ContributorsSchafer, Rollie, Mrotek, James J., Gross, Guenter W., Redden, David R., Busbee, David L., Beitinger, Thomas L.
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatvi, 135 leaves : ill., Text
RightsPublic, Criswell, Darrell W. (Darrell Wayne), Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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