Olfactory transduction mechanisms are best studied when specific blocking agents are available with which to modify cellular responses to odorant stimulation. This study is an electrophysiological investigation of functional group-specific olfactory acceptor mechanisms using ethylbromo acetate (EtBrAc), a World War I war gas which inhibits olfactory responses to odorant stimulation. The major findings of this investigation show that (1) vaporous EtBrAc is found to be a quick and effective inhibitor of electroolfactogram (EOG) responses to odorant stimulation, (2) isoamyl acetate is shown to protect EOG responses to a wide variety of odorants, inclusive of itself, from the inhibition effect of EtBrAc treatment, and (3) amine acceptor sites exist which are resistant to the inhibitory effects fo EtBrAc treatment.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc503901 |
| Date | 08 1900 |
| Creators | McClure, Fred Leland |
| Contributors | Schafer, Rollie, Barker, David J. |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | vii, 75 leaves : ill., Text |
| Rights | Public, McClure, Fred Leland, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved. |
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