The family of Crk adaptor proteins is integral to the molecular signaling of cellular migration. Only limited research has demonstrated a role in human carcinogenesis. Through the analysis of human breast cancers with immunohistochemistry, there is a near significant association implicating Crk proteins over-expression and a worsened overall survival. There was no statistical difference in a relation to nodal status. The RNA interference of Crk in human cancer cell lines caused a significant decrease in cell migration. This in vitro suppression of a malignant characteristic could provide a new avenue towards the molecular targeting of breast cancer that may eventually benefit patient outcomes.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.81608 |
| Date | January 2004 |
| Creators | Chan, Gabriel |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002198828, proquestno: AAIMR12411, Theses scanned by UMI/ProQuest. |
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