We demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release. (C) 2017 The Authors. Published by Elsevier GmbH.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/626294 |
| Date | 06 1900 |
| Creators | Lin, Shengtao, Shah, Anant, Hernández-Gil, Javier, Stanziola, Antonio, Harriss, Bethany I., Matsunaga, Terry O., Long, Nicholas, Bamber, Jeffrey, Tang, Meng-Xing |
| Contributors | Univ Arizona, Dept Med Imaging |
| Publisher | ELSEVIER GMBH, URBAN & FISCHER VERLAG |
| Source Sets | University of Arizona |
| Language | English |
| Detected Language | English |
| Type | Article |
| Rights | © 2017 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license. |
| Relation | http://linkinghub.elsevier.com/retrieve/pii/S2213597916300593 |
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