Organometallic allylation for the formation of C-C bonds has been a widely developed area over the past several decades for the formation of homoallylic alcohols and amines. One such pathway, the eponymous Hosomi-Sakurai reaction involves the Lewis acid-catalyzed addition of an allylic silane to an acetal, carbonyl, or imine. This work demonstrates an example of a Hosomi-Sakurai reaction using 1,2-ditosyl diazetidine as a slow release formaldimine precursor with good yield and high selectivity. Another less classical field, C-H activation, has also been around for several decades, but has recently exploded in new innovations. Through C-H activation chemists are able to bypass the need for functional groups that are substituted out, but instead utilizes the C-H bond as a synthon for further functionalization. This work will also demonstrate a modular approach for the synthesis of several ruthenium complexes with the potential to catalyze C-H activation.
Identifer | oai:union.ndltd.org:MSSTATE/oai:scholarsjunction.msstate.edu:td-4313 |
Date | 10 August 2018 |
Creators | Baine, Jonathan |
Publisher | Scholars Junction |
Source Sets | Mississippi State University |
Detected Language | English |
Type | text |
Format | application/pdf |
Source | Theses and Dissertations |
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