The main electrophilic source used in radiolabelling is [18F]F2, which is highly reactive, toxic and requires specialist equipment for safe handling. The Gouverneur group has initiated a research programme focused on the preparation of new stable and easy-to-handle N-18F reagents. In the development of [18F]radiolabelling reactions it would be extremely valuable to develop a library of selective N-18F reagents possessing reactivity tailored to the desired chemical transformation. The aim of this thesis is to further assess the scope of electrophilic N- 18F reagents in new transformations for the construction of C-18F bonds.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:604495 |
| Date | January 2014 |
| Creators | Stenhagen, Ida Sofia Refsholt |
| Contributors | Gouverneur, Veronique |
| Publisher | University of Oxford |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://ora.ox.ac.uk/objects/uuid:871a7e8c-a4d3-4acb-a25d-5946dec2f44d |
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