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Efficacy of Novel Pyridinium Oximes in Preventing Neural Damage

Organophosphates are neurotoxic compounds that inhibit acetylcholinesterase producing excess cholinergic stimulation. This produces various toxic signs including excitotoxic neuronal damage. Oximes can be used as a treatment for organophosphate poisoning by reactivating inhibited acetylcholinesterase. Traditional oximes do not penetrate the blood-brain barrier, limiting protection of the central nervous system. Novel, brain-penetrating oximes have the potential to protect the brain from organophosphate induced damage. Adult male rats were used to examine the ability of model organophosphates to produce neuropathology and the ability of novel oximes to prevent this damage. Additionally, adult male rats were used to examine changes in gene expression of the MAP kinase system resultant of treatment with model organophosphates and novel oximes. Results of these experiments support that the model organophosphates can be used to study neurodegeneration, the novel oximes may prevent neurodegeneration, and both organophosphates and novel oximes affect expression of MAP kinase genes.

Identiferoai:union.ndltd.org:MSSTATE/oai:scholarsjunction.msstate.edu:td-2831
Date08 December 2017
CreatorsLeach, Charles Andrew
PublisherScholars Junction
Source SetsMississippi State University
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceTheses and Dissertations

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