Epidemiological studies have described a link between chronic inflammatory
conditions, such as diabetes or obesity, and EOC suggesting that systemic inflammation
may increase the risk of the disease. The purpose of this study was to identify the impact
of prolonged exposure to low-grade inflammation on EOC tumorigenicity. We
hypothesized that exposure to this inflammation would accelerate ovarian tumor growth.
In vitro, normal and transformed ovarian epithelial cells had limited responsiveness to
inflammatory cytokines. In vivo, LPS-induced low-grade chronic systemic inflammation
accelerated EOC progression primarily through enhanced angiogenesis. Evaluation of the
relationships between chronic systemic inflammation and EOC may provide a role for
anti-inflammatory treatment in combinational EOC therapies. Additionally, as the rate of
metabolic disorders increases in the Western world the results from this work may
facilitate the advancement of complimentary therapeutic interventions for other cancers
that are influenced by inflammation.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OGU.10214/3881 |
| Date | 28 August 2012 |
| Creators | Kerr, Amanda |
| Contributors | Petrik, Jim |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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