Submitted by Sandra Pereira (srpereira@ufrrj.br) on 2016-09-12T18:07:34Z
No. of bitstreams: 1
2011 - Paula Cardoso de Almeida Silva.pdf: 463902 bytes, checksum: 375c57bac0b880fd3baf2320ee7abb93 (MD5) / Made available in DSpace on 2016-09-12T18:07:34Z (GMT). No. of bitstreams: 1
2011 - Paula Cardoso de Almeida Silva.pdf: 463902 bytes, checksum: 375c57bac0b880fd3baf2320ee7abb93 (MD5)
Previous issue date: 2012-01-25 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Embryo transfer (ET) is one of the most prominent techniques in the expansion of horse
breeding, enabling the production of more products of a single mare per year, thus increasing
the number of animals with high genetic value. The hormonal control of ovulation can be
used as a tool to optimize the reproductive parameters and reduce the costs in an ET program.
This study compared the effectiveness of lower doses than those traditionally used of
Deslorelin and hCG, evaluating the time between ovulation and induction, the recovery rates
and embryo attachment. The study was conducted at the Department of Animal Reproduction
and Evaluation of UFRRJ. We conducted follow-up of 85 estrous cycles of Breton Postier and
Mangalarga Marchador mares, when the mares presenting an ovarian follicle ? 35 mm, they
were divided randomly into one of three treatments: G1 (n = 32) - treatment with 1000 IU (1.0
ml iv) of hCG (Chorulon ? - Intervet Schering-Plough Animal Health), G2 (n = 28) -
treatment with 0.75 mg (0.75 ml iv) Deslorelin (Botupharma) and G3 (n = 28) - Treatment
with 1.0 ml saline iv. Twenty four hours after application, ultrasound evaluation of ovarian
was held every six hours up to ovulation. The donors were inseminated the day after induction
and embryo collection took place in nine days after ovulation. The recovered embryos were
immediately transferred to recipients previously synchronized, these pregnancy diagnosis was
performed at 15 and 30 days old embryo. Data regarding the time between ovulation and
induction and characteristics of follicular development were analyzed using analysis of
variance (ANOVA), and the averages of these data were analyzed when needed by the Tukey
test. The data regarding the percentage of mares ovulated in different periods, were analyzed
using the Qui-quadrado (?2) 5%. In the case of embryo recovery rate, the data were analyzed
using the Fisher exact test, however in relation to pregnancy rate was not possible to perform
statistical analysis due to low sample size. The percentage of ovulation in up to 36 hours for
G1, G2 and G3 were 34.4%, 13.3% and 8.7%, between 36 and 42 hours were 62.5%, 56.7%
and 8.7%, from 42 to 48 hours were 0%, 20% and 13%, more than 48 hours were 3.1%, 10%
and 69.6% respectively. Having thus a significant difference between treated and control
groups (p <0.05). The embryo recovery rate was 75% (6/8) in G1 and G2, and 44.4% (4/9) in
group G3, there was no significant difference between groups (p> 0.05). The rate of
pregnancy at fifteen days old embryo was 69.2% (9/13). Thus the lower doses commonly
used with inducing agents in question, were effective in promoting ovulation within 48 hours,
but the use of these didn't result in significant improvement in the rates of embryo recovery. / A transfer?ncia de embri?es (TE) ? uma das t?cnicas de maior destaque na expans?o da
equideocultura, possibilitando a produ??o de maior n?mero de produtos de uma mesma ?gua
por ano, aumentando assim o n?mero de animais com alto valor gen?tico. O controle
hormonal do momento da ovula??o pode ser usado como uma ferramenta para otimizar os
par?metros reprodutivos e reduzir os custos em um programa de TE. O presente estudo
comparou a efici?ncia de doses mais baixas do que as tradicionalmente utilizadas de hCG e
Deslorelina avaliando o tempo entre a indu??o e a ovula??o, as taxas de recupera??o e fixa??o
embrion?ria. O estudo foi desenvolvido no Departamento de Reprodu??o e Avalia??o Animal
da UFRRJ. Foi realizado o acompanhamento de 85 ciclos estrais de ?guas da ra?a Bret?o
Postier e Mangalarga Marchador, onde as ?guas ao apresentarem um fol?culo ovariano ? 35
mm foram divididas de maneira aleat?ria em um dos tr?s tratamentos: G1 (n = 32) ?
tratamento com 1000 UI (1,0 ml i.v.) de hCG (Chorulon? - Intervet Schering-Plough Animal
Health), G2 (n = 30) ? tratamento com 0,75 mg (0,75ml i.v.) de Deslorelina (Botupharma) e
G3 (n=23) ? tratamento com 1,0 ml i.v. de solu??o salina. Vinte quatro horas ap?s a
aplica??o, a avalia??o ultrassonogr?fica dos ov?rios passou a ser realizada a cada seis horas
at? a detec??o da ovula??o. As ?guas doadoras foram inseminadas no dia seguinte a indu??o e
as coletas de embri?o aconteceram no dia 9 ap?s a ovula??o. Os embri?es recuperados foram
imediatamente transferidos para receptoras previamente sincronizadas, sendo o diagn?stico de
gesta??o realizado aos 15 e 30 dias de idade embrionaria. Os dados referentes ao tempo entre
indu??o e ovula??o e caracter?sticas do desenvolvimento folicular, foram analisados pelo
m?todo de An?lise de Vari?ncia (ANOVA), sendo as m?dias desses dados analisadas quando
necess?rio pelo teste de Tukey. Os dados referentes ao percentual de ?guas ovuladas em
diferentes per?odos, foram analisados atrav?s do Qui-quadrado (?2) 5%. Em se tratando da
taxa de recupera??o embrion?ria, os dados foram analisados atrav?s do teste Exato de Fisher,
j? em rela??o a taxa de gesta??o n?o foi poss?vel realizar an?lise estat?stica devido ao baixo
n?mero amostral. Os percentuais de ovula??o em at? 36 horas nos grupos G1, G2 e G3, foram
34,4 %, 13,3% e 8,7%, entre 36 e 42 horas, 62,5%, 56,7% e 8,7%, entre 42 e 48 horas, 0%,
20% e 13%, acima de 48 horas 3,1%, 10% e 69,6%, respectivamente. Havendo dessa maneira
diferen?a significativa entre os grupos tratados e o controle (p < 0,05). A taxa de recupera??o
embrion?ria foi de 75% (6/8) nos grupos G1 e G2 e 44,4% (4/9) no grupo G3; n?o houve
diferen?a significativa entre os grupos (p > 0,05). J? a taxa de gesta??o aos quinze dias de
idade embrion?ria foi de 69,2% (9/13). Deste modo as doses inferiores ?s comumente
utilizadas, dos agentes indutores em quest?o, foram eficientes em promover a ovula??o em at?
48 horas, mas o uso destes, n?o resultou em melhora significativa nos ?ndices de recupera??o
embrion?ria
Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1198 |
Date | 25 January 2012 |
Creators | Silva, Paula Cardoso de Almeida |
Contributors | Jacob, J?lio Cesar Ferraz, Dell' Aqua Junior, Jos? Antonio, Mello, Marco Roberto Bourg de |
Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas), UFRRJ, Brasil, Instituto de Veterin?ria |
Source Sets | IBICT Brazilian ETDs |
Language | Portuguese |
Detected Language | English |
Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
Format | application/pdf |
Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
Rights | info:eu-repo/semantics/openAccess |
Relation | 6 REFER?NCIAS ALLEN, W. R. Artificial control of the mare?s oestrus cycle. Veterinary Record, v. 104, p. 166, 1977. ALLEN, W. R.; COOPER, M. J. Prostraglandins. In: McKINNON, A. O.; VOSS, J. L. Equine Reproduction. Malvern: Lea & Febiger, 1993. Cap. 8, p.69-80. ALLEN, W. R. Fetomaternal interactions and influences during equine pregnancy. Reproduction, v. 121, p. 513- 527, 2001. ALLEN, W. R.; WILSHER, S.; TURNBULL, C.; STEWART, F.; OUSEY, J.; ROSSDALE, P. D.; FOWDEN, A. L. Influence of maternal size on placental, fetal and postnatal growth in the horse: I. Development in utero. Reproduction, v. 123, p. 445-53, 2002. ALLEN, W. R.; WILSHER, S.; TIPLADY, C.; BUTTERFIELD, R. M. The influence of maternal size on pre and post natal growth in the horse: III Postnatal growth. Reproduction, v. 127, p. 67-77, 2004. ALONSO, M. A. Efeito das caracter?sticas uterinas e dia do ciclo na taxa de prenhez e n?veis s?ricos de progesterona em ?guas candidatas ? receptora de embri?o. 2007. 87p. Disserta??o (mestrado) - Programa de P?s-Gradua??o em Medicina Veterin?ria, Universidade Estadual Paulista, Botucatu, 2007. ALONSO, M. A. Sele??o, manejo e fatores que influenciam as taxas de prenhez em ?guas receptoras de embri?o In: XXII REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRI?ES, Guaruj?. Anais... S?o Paulo: Acta Science Veterinariae, v. 36 (supl. 1), p. 207-214, 2008. ALVARENGA, M. A.; ALVARENGA, F. C. L.; MEIRA, C. Some modifications in the thechnique used to recover equine embryo. In: International Symposium on Equine Embryo Transfer, 13., 1992, Buenos Aires, Argentina. Resumos... Buenos Aires, p. 34-35, 1992. ALVARENGA, M. A; CARMO, M. T; OLIVEIRA, J. V. Transfer?ncia de embri?es na esp?cie eq?ina. Apostila de transfer?ncia de embri?es na esp?cie eq?ina. Botucatu. 2008. ALVARENGA, M. A. Problemas e solu??es em programas de transfer?ncia de embri?es em equinos no Brasil. In: XXIV REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRI?ES, Porto de Galinhas. Workshop 2: Estrat?gias de otimiza??o da produ??o de embri?es em programas de TE em eq?inos,Pernambuco: Acta Science Veterinariae, p.59-62, 2010. AMANN, R. P.; PICKETT, B. W. Principles of cryopreservation ans a review of cryopreservation of stallion spermatozoa. Journal of Equine Veterinary Science, v. 7, p. 145-173, 1987. 49 ARRUDA R. P.; VISINTIN J. A.; FLEURY, J. J.; GARCIA A. R.; MADUREIRA, E. H.; CELEGHINI E. C. C.; NEVES NETO, J. R. Existem rela??es entre tamanho e morfoecogenicidade do corpo l?teo detectados pelo ultra-som e os teores de progesterona plasm?tica em receptoras de embri?es eq?inos? Brazilian Journal of Veterinary Research and Animal Science, v. 38, p. 233-239, 2001. ATAYDE, L. M. Caracter?sticas do ciclo reprodutivo da ?gua no norte de Portugal. Trabalho de s?ntese, provas de aptid?o pedag?gica e capacidade cientifica. ICBAS, p. 1-64, 2008. BARBACINI, S.; ZAVAGLIA, G.; GULDEN, P.; MARCHI, V.; NECCHI, D. Retrospective study on the efficacy of hCG in an equine artificial insemination programme using frozen semen. Equine Veterinary Education, v. 12, n. 6, p. 312-317, 2000. BEAL, J. Indu??o da ovula??o em ?guas crioulas com diferentes dose de Gonadotropina Cori?nica Humana. 2008. 39p. Disserta??o (Mestrado) . Programa de p?s gradua??o em Medicina Veterin?ria - Universidade de Santa Maria, Rio Grande do Sul, 2008. BEREZOWSKI, C. J.; STITCH, K. L.; WENDT, K. M.; VEST D. J. Clinical comparison of 3 products available to hasten ovulation in cyclic mares. Journal of EquineVeterinary Science, v. 24, n.6, p. 231-233, 2004. BERGFELT, D. R.; GINTHER, O. J. Delayed follicular development and ovulation following inhition of FSH with equine follicular fluid in the mare. Theriogenology. v. 26, p. 733-747, 1985. BERGEFELT, D.R. Ovarian follicular waves dynamics in mares. Arquivos da Faculdade de Veterin?ria UFRGS, v. 26, p. 104-124, 1998. BERGEFELT, D.R. Estrous synchronization. In: Samper J.C. (Ed) Equine breeding management and artificial insemination. Saunders Comp, Pennsylvania., p.229-246, 1999. BERGEFELT, D. R. Estrous synchronization. mare In: SAMPER J.C.; PYCOCK, J.; McKINNON, O. Equine breeding management and artificial insemination. Philaddelphia: Saunders, p. 195 ? 228, 2000. BLANCHARD, T. L.; VARNER, D. D.; LOVE, C. C.; BRINSKO, S. P.; RIGBY, S. L.; SCHUMACKER, J. Manual of equine reproduction. Publicado por: C.V. MOSBY, 2?ed., p.25-26, 2003. BRAGG, N. D.; PIERSON, R. A.; BUSS, D. G.; CARD, C. E. Transrectal Tonometric Measurement of Follicuar Softening and Computer Assisted Ultrasound Image Analisys of Follicular Wall Echotexture During Estrus in Mares. Proceedings of the Annual Convention of the AAEP, v. 47, p. 242-245, 2001. BRINSKO, S.; VARNER, D. D.; BLANCHARD, T. L. Transported Equine Semen. Recent Advances in Equine Reproduction, 2000. 50 CAMILO, F.; VANNOZZI, I.; LUZIO, B. D.; ROMANGNOLI, S.; ARIA, G.; ALLEN, W. R. Successful non-surgical transfer of horse embryos to mule recipients. Reproduction in Domestical Animals, v. 38, p. 380-385, 2003. CAMILLO, F.; PACINI, M.; PANZANI, D.; VANNOZZI, I.; ROTA, A.; ARIA, G. Clinical use of twice daily injections of buserelin acetate to induce ovulation in the mare. Veterinary Research Communications, v. 28 (Suppl 1), p. 169?72, 2004. CARLUCCIO, A.; PANZANI, S.; TOSI, U.; FAUSTINI, M.; DE AMICIS, I.; VERONESI, M. C. Efficacy of hCG and GnRH for inducing ovulation in the jenny. Theriogenology, v. 68, p. 914?919, 2007. CARNEIRO, G. F. Transfer?ncia de embri?es em equinos. In: Congresso Brasileiro de Reprodu??o Animal, 16, 2005, Goi?nia, GO. Anais... Goi?nia, p. 1-6, 2005. CARNEVALE, E. M.; RAMIREZ, R. J.; SQUIRES, E. L.; ALVARENGA, M. A.; VANDERWALL, D. K.; MCCUE, P. M. Factors affecting pregnancy rates and early embryonic death after equine embryo transfer. Theriogenology, v. 54, p. 965-979, 2000. CARVALHO, G. R. Estudos de alguns aspectos da transfer?ncia de embri?es equinos. 2000. 102p. Tese (doutorado) ? Departamento de Zootecnia, Universidade Federal de Vi?osa, Vi?osa, 2000. CARVALHO, G.R; FILHO, J.M.S; FONSECA, F.A; RUAS, J.R.M; BORGES, A.M. Influ?ncia da t?cnica de coleta sobre a taxa de recupera??o de embri?es eq?inos. Arquivo Brasileira de Medicina Veterin?ria e Zootecnia, n. 5, 2001. CARMO, M. T. Compara??o entre doses constantes e decrescentes de extrato de Pituit?ria eq?ina na indu??o de superovula??o em ?guas. 2003. 156p. Disserta??o (Mestrado em Reprodu??o Animal) - Universidade Estadual Paulista, Faculdade de Medicina Veterin?ria e Zootecnia, Botucatu, 2003. CHAVATTE, P.; PALMER, E. Induction of ovulation in the mare. Equine Veterinary Education, v. 10, n.1, p. 26-30, 1998. COSTA, A.L.A. Controle reprodutivo e transfer?ncia de embri?es em eq?inos. 2010, 33p. Relat?rio final de est?gio Mestrado Integrado em Medicina Veterin?ria ? Instituto de Ci?ncias Biom?dicas Abel Salazar, Universidade do Porto, Porto, 2010. COX, T. J.; SQUIRES, E. L.; HONDACT; CARNEVALE, E.M. Effect of Follicle Size and Follicle-Stimulating Hormone on Ovulation Induction and Embryo Recovery in the Mare. Journal of Equine Veterinary Science, v. 29, n. 4, 2009. CUERVO-ARANGO, J.; NEWCOMBE, J. R. How to reliable is to use the preovulatory follicular diameter of a previous cycle as a guide to optimize breeding time in the mare? In: Proceedings of the European Equine Meeting of the Year SIVE FEEVA Congress, Italy, p. 357-358, 2008. 51 CUERVO-ARANGO, J.; AGUILAR, J.; NEWCOMBE, J.R. Effect of type of semen, time of insemination relative to ovulation and embryo transfer on early equine embryonic vesicle growth as determined by ultrasound. Theriogenology, v. 71, p. 1267-1275, 2009. DAELS, P. F.; STABENFELD, G. H.; HUGHES, J. P.; ODENSVIK, K.; KINDAHL, H. Effects of flunuxin meglumine on endotoxin-induced prostaglandin F2? secretion during early pregnancy in the mare. American Journal of Veterinary Research, v. 52, p. 76-281, 1991. DAELS, P. F.; HUGHES, J. P. The normal estrous cycle. In: McKINNON, A.O.; VOSS, J.L. Equine Reproduction. Philadelphia: Lea e Febiger, p. 121-132, 1993. DAELS, P. Embryo transfer tips and trics. In: Proceedings 5th European Veterinary Conference, Voorjaarsdagen, Amsterdam, p. 213-215, 2007. DAY, F. T. Ovulation and the descent of the ovum in the fallopian tube of the mare after treatment with the gonadotrophic hormones. Journal of Agricultural Science, Cambridge, v. 29, p.459-469, 1939. DESKUR, S. Twinning in the Thoroughbred mares in Poland. Theriogenology, n. 23, p. 711- 718, 1985. DONADEU, F. X.; GINTHER, O. J. Follicular waves and circulating concentrations of onadotropins inhibin and estradiol during the anovulatory season in mares. Reproduction, v. 124, p. 975-885, 2002. DOUGLAS, R. H. Review of induction of superovulation and embryo transfer in the equine. Theriogenology, v. 11, p. 33-36, 1979. DOUGLAS, R. H. Some aspects of equine embryo transfer. Journal of Reproduction and Fertility, v. 32, p. 405-408, 1982. DRIANCOURT, M. A.; PALMER, E. Seasonal and individual effects on ovarian and endocrine responses of mares to a synchronization treatment with progestagen-impregnated vaginal sponges. Journal of Reproduction and Fertility, v. 32, p. 283-291, 1982. DRIANCOURT, M. A. Regulation of ovarian follicular dynamics in farm animals: implications for manipulation of reproduction. Theriogenology, v. 55, p. 1211-1239, 2001. DUCHAMP, G.; BOUR, B.; COMBARNOUS, Y.; PALMER, E. Alternative solutions to hCG induction of ovulation in the mare. Journal of Reproduction and Fertility. Suppl. v. 35, p. 221 - 228, 1987. ENGLAND, G. C. W. Manipulation of Cyclical Activity. Fertility and Obstetrics in the Horse V, 3rd Ed, Blackwell Publishing, p. 43-50, 2005. 52 EVANS, M. J.; IRVINE, C. H. G. The serum concentrations of FSH, LH and progesterone during the oestrous cycles and pregnancy in the mare. Journal Reproduction Fertility, Suppl 23, p. 193-200, 1975. EVANS, A. C. O. Characteristics of ovarian follicle development in domestic animals. Reproduction in Domestic Animals, v. 38, p. 240-246, 2003. FARQUHAR, V. J.; McCUE, P. M.; VANDERWALL, D. K.; SQUIRES, E. L. Efficacy of the GnRH agonist Deslorelin acetate for inducing ovulation in mares relative to age of mare and season. Journal of Equine Veterinary Science. v. 20, n. 11, p. 722 ? 725, 2000. FILHO, A. N. R. Efeito do tratamento com baixa dose de extrato de Pituit?ria ou FSH purificado eq?ino no crescimento folicular, taxa de ovula??o e recupera??o embrion?ria em ?guas. 2005. 64p. Disserta??o (mestrado) ? Faculdade de Medicina Veterin?ria e Zootecnia, Universidade Estadual de S?o Paulo, Botucatu,2005. FLEURY, J. J.; ALVARENGA, M. A.; COSTA NETO, J. B. F.; PAPA, F. O. Transfer?ncia de embri?es em eq?inos. Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v. 39, p. 485-487, 1987. FLEURY, J. J.; ALVARENGA, M. A. Effects of collection day on embryo recovery and pregnancy rates in a nonsurgical equine embryo transfer program. Theriogenology, v. 51, p. 261, 1999. FLEURY, J. J.; PINTO, A. J.; CELEGHINI, E. C. C.; LIMA, C. G.; ARRUDA, R. P. Efeitos do garanh?o e t?cnica reprodutiva sobre os ?ndices de recupera??o e gesta??o em um programa de transfer?ncia de embri?es na ra?a mangalarga. Brazilian Journal of Veterinary Research and Animal Science, v. 38, n. 1, p. 34-37, 2001. FLEURY, P. D. C.; ALONSO, M. A.; BALIEIRO, J. C. C. Avalia??o da receptora: efeito de caracter?sticas uterinas e tempo de ovula??o. In: XVIII REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRIOES, Anais... Arax?, Acta Scientiae Veterinariae, v. 34, n. 1; p. 502, 2006. FLEURY, P. D. C.; ALONSO, M. A; SOUSA, F. A. C.; ANDRADE, A. F. C; ARRUDA, R. P. Uso da gonadotrofina cori?nica humana (hCG) visando melhorar as caracter?sticas reprodutivas e fertilidade de receptoras de embri?es eq?ino. Revista Brasileira de Reprodu??o Animal, v. 31, n.1, p. 27-31, 2007. FITZGERALD B. P.; McMANUS C. J. Photoperiodic versus metabolic signals as determinants of seasonal anestrus in the mare. Biology of Reproduction, v. 63, p. 335-340, 2000. FORHEAD, A. J.; OUSEY, J. C.; ALLEN, W. R.; FOWDEN, A. L. Postanal insulin secretion and sensitivity after manipulation of fetal growth by embryo transfer in the horse. Journal Endocrinology, v. 181, p. 459-67, 2004. 53 FORTUNE, J. E. Ovarian follicular growth and development in mammal. Biology of Reproduction, v. 50, p. 225-232, 1994. FORTUNE, J. E. Selection and maintenance of the dominant follicle: An introduction. Biology of Reproduction, v. 65, p. 637, 2001. GASTAL, E. L.; GASTAL, M. O.; BERGFELT, D.R.; GINTHER, O. J. Role of diameter differences amog follicles in selection of a future dominant follicle in mares. Biology of Reproduction, v. 57, p. 1320-1327, 1997. GASTAL, E. L.; BERGFELT, D. R.; NOGUEIRA, G. P.; GASTAL, M. O.; GINTHER, O. J. role of luteinizing hormone in follicle deviation based on manipulating progesterone concentrations in mares. Biology of Reproduction, v. 61, p. 1492-1498. 1999. GASTAL, E. L., GASTAL, M. O., NOGUEIRA, G. P., BERGFELT, D. R., GINTHER, O. J. Temporal interrelationships among luteolysis, FSH, and LH concentrations and follicle deviation in mares. Theriogenology, v. 53, p. 925-940, 2000. GASTAL, E. L.; SILVA, L. A.; GASTAL, M. O., EVANS, M. J. Effect of different doses of hCG on diameter of the preovulatory follicle and interval to ovulation in mares. Animal Reproduction Science, v. 94, p. 186?190, 2006. GINTHER, O. J.; Occurrence of anoestrous, estrus, diestrus and ovulation over 12 month period in mares. American Journal of Veterinary Research, v. 35, p. 1173-1179, 1974. GINTHER, O. J.; PIERSON, R. A. Regular and irregular characteristics of ovulation and the interovulatory interval in mares. Journal Equine Veterinary Science, v. 9, p. 4?12, 1989. GINTHER, O. J. Folliculogenesis during the transitional period and early ovulatory season in mares. Journal of Reproduction and Fertility, p. 311?320, 1990. GINTHER, O. J. Reproductive biology of the mare. 2a Ed. Wisconsin: Equiservices, p. 642, 1992. GINTHER, O. J.; BERGFELT, D. R. Growth of animal follicles and concentrations of FSH during the equine estrous cycles. Journal of Reproduction and Fertility, v. 99, p. 105-111, 1993. GINTHER, O. J. Selection of the dominant follicle in cattle and horses. Animal Reproduction Science, v. 60, p. 61-79, 2000. GINTHER, O. J.; BEG, M. A.; BERGFELT, D. R.; DONADEU, F. X.; KOT, K. Follicle selection in monovular species. Biology of Reproduction, v. 65, p. 638-647, 2001. GINTHER, O. J.; WOODS, B. G.; MEIRA, C.; BEG, M. A.; BERGFELT, D. R. Hormonal mechanism of follicle deviation as indicated by major versus minor follicular waves during the transition into the anovulatory season in mares. Reproduction, v. 126, p. 653-660, 2003. 54 GINTHER, O. J.; BEG, M. A.; GASTAL, M. O.; GASTAL, E. L. Follicle dynamics and selection in mares. Animal Reproduction, v. 1, n. 1, p. 45 ?63, 2004. GINTHER, O. J.; GASTAL, E. L.; GASTAL, M. O.; BEG, M. A. Regulation of circulating gonadotropins by the negative effects of ovarian hormones in mares. Biology of Reproduction, v. 73, p. 315-323, 2005. GINTHER, O. J.; GASTAL, E. L.; GASTAL, M. O.; BEG, M. A. Seasonal influenceon equinefollicle dynamics. Animal Reproduction Science, v. 1, n.1, p. 31-44, 2004. GINTHER, O. J.; GASTAL, E. L.; GASTAL, M. O.; BEG, M. A. Dynamics of the Equine Preovulatory Follicle and Periovulatory Hormones: What?s New? Journal of Equine Veterinary Science, v. 28, p. 454-460, 2008. GINTHER, O. J.; JACOB, J. C. F.; GASTAL, M. O. GASTAL, E. L.; BEG, M. A. Development of one versus multiple ovulatory follicles and associated systemic hormone concentrations in mares. Reproduction in Domestic Animals, v. 44, n. 3, p. 441-449, 2009a. GINTHER, O. J.; BEG, M. A.; GASTAL, E. L.; GASTAL, M. O.; COOPER, D. A. Treatment with human chorionic gonadotropin (hCG) for ovulation induction is associated with an immediate 17_-estradiol decrease and a more rapid LH increase in mares. Animal Reproduction Science, v. 114, p. 311?317, 2009b. GOMES, G. M.; JACOB, J. C. F.; DOMINGUES, I. B. Utilization of mares after first post partum ovulation as embryo recipients, In: 6th INTERNATIONAL SYNPOSIUM ON EQUINE EMBRYO TRANSFER, 2004, Rio de Janeiro, Brasil. Proceedings?Rio de Janeiro: 2004. GOMES, G. M.; GOMES, L. P. M. Fatores que influenciam a produ??o de embri?es em ?guas doadoras. In: XXII REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRI?ES, Guaruj?. Anais... S?o Paulo, Acta Science Veterinariae, v. 36 (supl.2), n.1, p. 199-206, 2008. GREENNHOFF,G.R.; KENNEY, R.M. Evaluation of reproductive status of pregnant mares. Journal of the American Veterinary Medical Association, v. 167, p. 449, 1975. GUERRA, P.; MEDEIROS, S. A. F. O agroneg?cio da equideocultura no Brasil. In: I SIMP?SIO MINEIRO DE EQUIDEOCULTURA, Vi?osa. Anais... Vi?osa, MG, p. 1-7, 2007. HAFEZ, E. S. E.; HAFEZ, B. Reproduction in farm animals, Philadelphia: Lea & Febiger, ed. 7, p. 509, 2000. 55 HINRICHS, K. Embryo transfer in the mare: a status report. Animal Reproduction Science, v. 33; p. 227-40, 1993. HIRSHFIELD, A. N. Comparison of granulose cell proliferation in small follicles of hypophysectomized, prepuberal and mature rats. Biology of Reproduction, v. 32, p. 979-987, 1985. HUDSON, J. J.; McCUE, P. M. How to increase embryo recovery rates and transfer success. In: 50th Annual Convention of the American Association of Equine Practitioners, Denver. Proceedings? Lexington: American Association of Equine Practitioners, p. 1473-1204, 2004. HUGHES, J.P.; STABENFELDT, G.H.; EVANS, J.W. Estrous cycle and ovulation in the mare. Journal American Veterinary Medical Association, v. 161, p. 1367-1374, 1972. HUGHES, J. P.; STABENFELDT, G. H.; EVANS, J. W. The oestrous cycle of the mare. Journal of Reproduction and Fertility, Suppl. 23, p. 161-166, 1975. IMEL, K.J. Recovery, culture and transfer of equine embryos. MS Thesis, Colorado State University, Fort Collins, CO, USA, 1981. INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTAT?STICA - IBGE. Produ??o da pecu?ria municipal. Dispon?vel em: <http://www.ibge.gov.br/home/> Acesso em: 24/5/2011. IVKOV, V.; IVANCEV, N.; VESELINOVIC, S.; GRUBAC, S.; VESEKINOVIC, S.; DOVENSKI, T.; MICKOVSKI, G.; KOCOSKI, L.; POPOVSKI, K.. Ultrasonic Measurement of Follicle?s Diameter in Estrus of Mares. In: 7th Conference for Ovine and Caprine Production & 5th Symposium on Animal Reproduction , Ohrid, Proceedings ? p. 1-3, 1999. JACOB, J. C. F.; DOMINGUES, I. B.; GASTAL, E. L. et al. The impacto of degree of synchrony between donors and recipients in a commercial equine embryo transfer program. Theriogenology, v. 57, n. 1, p. 545, 2002. JACOB, J. C.; GASTAL, E. L.; GASTAL, M. O.; CARVALHO, G. R.; BEG, M. A.; GINTHER, O. J. Follicle Deviation in Ovulatory Follicular Waves with One or Two Dominant Follicles in Mares. Reproduction Domestic Animals, v. 44, p. 248?254 2009. JACOB, J. C. F.; SANTOS, G. O.; OLIVEIRA, J.P.; GASTAL, M. O.; GASTAL, E.L. Evaluation of reproductive parameters in a commercial equine embryo transfer program. Animal Reproduction Science, v.121, n. 1, p. 305-306, 2010. JACOB, J. C. F.; SANTOS, G. O.; S?, M. A. F.; OLIVEIRA, J. P. Uso cl?nico de HCG em um programa de transfer?ncia de embri?es equino: mitos e verdades. A Hora Veterin?ria, Ano 30, n.180, mar?o/abril, 2011. 56 KENNEY, R. M., CONDON, W., GARJAN, V. K., CHANNING, C. P. Morphological and biochemical correlates of equine ovarian follicles as a function of their stage of viability or atresia. Journal Reproduction Fertility, v. 27, p. 163-171, 1979. KNOTTENBELT, D.C.; LeBLANC, M.; LOPATE, C.; PASCOE, R.R. Equine Stud Farm Medicine and Surgery, Saunders Elsevier Science, 1? ed, p. 402, 2003. K?LLING, M.; ALLEN, W. R. Ovulation induction for embryo transfer: hCG versus GnRH analogue. Havemeyer Foundation Monograph Serie. n. 18, p. 54-55, 2005. LeBANC M.; LOPATE, C.; KNOTTENBELT, D.; PASCOE, R. The mare. Equine stud farm medicine and surgery V. Saunders Elsevier Science, 1? ed, p. 113-212, 2003. LeBLANC, M. M. Reproduction Deduction ? Part 2. In: Proceedings of North America Veterinary Conference, Orlando, 2006. LINCOLN, G. A. The pineal gland. In Austin, G.R. & Short, F. R.S. (eds). Reproduction in Mammals, Hormonal control of Reproduction. New York, Cambridge University Press, 2?ed, p. 52-75, 1987. LIRA, R. A.; PEIXOTO, G. C. X.; SILVA, A. R. Tranfer?ncia de embri?o equino: Revis?o. Acta Veterinaria Brasilica, v. 3, n.4, p. 132-140, 2009. LISA, H .M.; MEADOWS, S. Essential management practices in commercial equine embryo transfer. Proceedings 7th International Symposium on Equine Embryo Transfer, Cambridge, UK, p. 101-102, 2008. LOOMIS, P. R; SQUIRES, E. L. Frozen semen management in equine breeding programs Theriogenology, v. 64, p. 480-491, 2005. LOSINNO, L.; ALVARENGA, M. A. Fatores cr?ticos em programas de transfer?ncia de embri?es em equinos no Brasil e Argentina. . In: XVIII REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRI?ES, Arax?. Anais... Arax?: Acta Scientiae Veterinariae, v. 34, p. 39-49, 2006 MACHADO, M. S. Din?mica folicular em ?guas. In: Semin?rio do Curso de P?s-Gradua??o, S?o Paulo. Anais... S?o Paulo: Faculdade de Medicina Veterin?ria e Zootecnia da Universidade Estadual Paulista, Campus Botucatu, 20p, 2002. MAIO, J.R.G.; FLEURY, P.D.C.; SALES, J.N.S.; CREPALDI, G.A.; TEIXEIRA, A.A.; SOUZA, E.D.F.; BARUSELLI, P.S. Din?mica folicular de ?guas adultas c?clicas tratadas com diferentes indutores de ovula??o. In: XXIV REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRIOES, Porto de Galinhas. ANAIS?, p.365, 2010. MALINOWSKY, K. Recent advances in reproduction in horses. In: http://www.rce.rutgers.edu/pubs/pdfs/fs717, 2002. 57 McCRACKEN, J. A ., EDWARD, E. C.; LAMSA, J. C. Luteolisys: A Neuroendocrinemediated Event. Physiological Reviews, v. 79, n.2, p. 263-323, 1999. McCUE, P. M.; VANDERWALL, D. K.; KEITH, S. L.; SQUIRES, E. L. Equine embryo transfer: influence of endogenous progesterone concentration in recipients on pregnancy outcome. Theriogenology, v. 51, n. 1, p. 267, 1999. McCUE, P. M.; HUDSON, J. J.; BRUEMMER, J. E.; SQUIRES, E. L. Efficacy of hCG at inducing ovulation: A new look at an old issue. In: Proceedings of the 50 th annual convention of the American association of equine practioners, p. 510-513, 2004. McCUE, P. M.; MAGEE, C.; GEE, E. K. Comparison of Compounded Deslorelin and hCG for Induction of Ovulation in Mares. Journal of Equine Veterinary Science. v. 27, n. 2, p. 58-61, 2007. MCKINNON, A. O.; SQUIRES, E. L. Equine embryo transfer. Journal of the American Veterinary Medical Association, v. 192, p. 305-330, 1988. McKINNON, A. O.; BROWN, R. W.; PASSION, R. L. Increased ovulation rate in mares after immunization against recombinant bovine inhibin ?-subunit. Equine Veterinary. Journal. London, v. 24, p. 144-146, 1992. McKINNON, A. O.; VOSS, J. L. The estrous cycles. In: Mckinnon, Equine Reproduction., Malvern: Lea & Febizer, p. 114?189, 1993. McKINNON, A. O., NOBELLIUS, A. M., TARRIDA DEL MARMOL FIGUEROA, S. SKIDMORE, J., VASEY, J. R., TRIGG, T. E. Predictable ovulation in mares treated with an implant of the GnRH analogue deslorelin. Equine Veterinary Journal, v. 25, p. 321-323, 1993. McKINNON, A. O.; SQUIRES, E. L. Embryo transfer and related technologies. In: Current Therapy Equine Reproduction, Saunders, Missouri, p. 319-334, 2007. MEINERT, C. J. F.; SILVA, I.; KROETZ, E.; KLUG, T. E.; TRIGG, H. O.; HOPPEN; J?CHLE, W. Advancing the time of ovulation in the mare with a short-term implant releasing the GnRH analogue deslorelin. Equine Veterinary Journal, v. 25, p. 65-68,1993. MEIRA, C. Endocriologia da reprodu??o, din?mica folicular, superovula??o e transfer?ncia de embri?es na esp?cie eq?ina. Apostila do curso de insemina??o e transfer?ncia de embri?es em eq?inos. Botucatu, Outubro/2007. MELO, C. M.; PAPA, F. O.; MEDEIROS, A. S. L.; DELL'AQUA JR, J. A.; CARMO, M. T.; ARA?JO, G. M.; ALVARENGA, M. A. Efeito da Deslorelina e do extrato de pituit?ria equina na indu??o da ovula??o em ?guas. In: XIX REUNI?O ANUAL DA SBTE, 2005, Angra dos Reis. Anais? Rio de Janeiro: Acta Scientiae Veterinariae, v. 33, p. 193, 2005. 58 MONAHAN, M. W., AMOSS, M. S., ANDERSON, H. A., VALE, W. Synthetic analogs of the hypothalamic luteinizing hormone-releasing factor with increased agonist of antagonist properties. Biochemistry, v. 12, p. 4616-4620, 1973. MONNIAUX, D.; MONGET, P.; BESNARD, N.; HUET, C.; PISSELET, C. Growth factors and antral follicular development in domestic ruminants. Theriogenology, v. 47, p. 3-12, 1997. MOREL, M. D. ?Mare Insemination?, Equine Artificial Insemination VIII, Cabi Publishing, p. 302-336, 1999. MOREL, M. D. Endocrine control of reproduction in the mare. Equine reproductive physiology, breeding and stud management III, Cabi publishing, 2nd ed., p. 28-39, 2003. MOREL, M. C. G. D.; NEWCOMBE, J. R. The efficacy of different hCG dose rates and the effect of hCG treatment on ovarian activity: Ovulation, multiple ovulation, pregnancy, multiple pregnancy, synchrony of multiple ovulation; in the mare. Animal Reproduction Science. v.109, p. 189?199, 2008. MORENO, M. P.; OLIVEIRA, J. P.; SANTOS, G. O.; S?, M. A. F.; ECKER, M. K. C.; JACOB, J. C. F. Avalia??o da resposta ovulat?ria de ?guas da ra?a mangalarga marchador a diferentes doses de hCG. In: XXIV REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRIOES, Porto de Galinhas. ANAIS? Pernambuco: Acta Scientiae Veterinariae , p. 381, 2010. MORRIS, L. H.; ALLEN, W. R. Reproductive efficiency of intensively managed Thoroughbred mares in Newmarket. Equine Veterinary Journal, v. 34; p. 51-60, 2002. MOYA-ARAUJO, C. F.; BRAGA, J. T.; SCHIRATO, D.; ARAUJO, D. C.; DELL?AQUA JR., J. A.; ARAUJO, G. H. M. Indu??o da ovula??o de fol?culos com diferentes di?metros com desorelina em ?guas. . In: XXIV REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRIOES, Porto de Galinhas. ANAIS? Pernambuco: Acta Scientiae Veterinariae, p. 412, 2010. MOZZAQUATRO, F. D. Aspira??o folicular na ?gua para indu??o da fun??o l?tea. 2008. 70p. Tese (Doutorado) ? Programa de P?s-Gradua??o em Medicina Veterin?ria, Universidade Federal de Santa Maria, Rio Grande do Sul, 2008. MUMFORD, E. L.; SQUIRES, E. L.; J?CHLE, W.; HARRISON, L. A.; NETT, T. M.; TRIGG, T. E. Use of deslorelin short-term implants to induce ovulation in cycling mares during three consecutive estrous cycles. Animal Reproduction Science, v. 39, p. 129-140, 1995. NAMBO, Y.; NAGAOKA, K.; TANAKA, Y.; NAGAMINE, N; SINBO, H.; NAGATA, S.; YOSHIHARA, T.; WATANABE, G.; GROOME, N. P.; TAYA, K. Mechanisms responsible for increase in circulating inhibin levels at time ovulation in mares. Theriogenology, v. 57, p. 1707-1717, 2002. 59 NEELY, D. P.; KINDAHL, H.; STABENFELDT, G. H.; EDQVIST, L. E.; HUGHES, J. P. Prostaglandin release patterns in the mares. Physiological, pathophysiological and therapeutic responses. Journal of Reproduction and Fertility, Suppl. 27, p. 181-189, 1979. NEELY, D.P. Reproductive endocrinology and fertility in the mare. In: Neely, Liu, Hillman (eds). Equine Reproduction. Vet. Learning Systems Co., INC, p. 12-22, 1983. OGURI, N.; TSUTSUMI, Y. Nonsurgical recovery of equine eggs, and an attempt at nonsurgical egg transfer in horses. Journal of Reproduction and Fertilility, v. 31, p. 187- 195, 1972. OGURI, N.; TSUTSUMI, Y. Non-surgical transfer of equine embryos. Archives of Andrology, v. 5, p. 108, 1980. PALHARES, M. S. Insemina??o artificial em equinos, incluindo transporte de s?men. In: IV Simp?sio Nacional de Reprodu??o Animal. Belo Horizonte. Anais... Campinas: Funda??o Cargiul, 1988. PALMER, E. Induction of ovulation. In: McKinnon, A.O. & Voss, J.L. Equine Reproduction. Malvern: Lea & Febiger, p.344-347, 1993. PERES, K. R.; TRINQUE, C. L. N.; LIMA, M. M.; DUARTE, M. C.; MEIRA, C. Nonsurgical equine embryo transfer: a retrospective study. Theriogenology, v. 57, p. 558-558, 2002. PIERSON, R. A, GINTHER, O.J. Ultrasonic evaluation of the preovulatory follicle in the mare, Theriogenology, v. 24, p. 359-368, 1985. PIERSON, R. A.; GINTHER, O. J. Follicular population dynamics during the estrus cycle of the mare. Animal Reproduction Science, v. 14, n. 3, p.2 19-31, 1987. PIMENTEL, C. A.; TAROUCO, A. K.; HAMMES, A. M. Ovula??es M?ltiplas Em ?guas Abatidas em Pelotas- RS. Ci?ncia Rural, v. 25, n. 2, p. 271-275, 1995. PINTO, C. R. F.; MEYERS, P. J. Control and synchronization.of the estrous cycle and ovulation. In: Youngquist R.S. & Threlfall W.R. (Ed.) Current therapy in large animal theriogenology. Elsevier Science, St. Louis, p. 91-98, 2007. PYCOCK, J. F.; DIELEMAN, S.; DRIFJIHOUT, P.; VAN DER BRUG, Y.; OEI, C.; VAN DER WEIJDEN, G. C. Correlation of plasma concentrations of progesterone and oestradiol with ultrasound characteristics of the cycling mare. Reproduction Domestic Animal, v. 30, p. 224-227, 1995. PYCOCK, J.F. ?Artificial Insemination? Proceedings of the 10th International Congress of World Equine Veterinary Association, Moscow, p. 224-234, 2008. 60 REITER, R. J. Comparative physiology: pineal gland. Annual Review Physiology, v. 35, p. 305-328, 1973. ROCHA, A. N.; LOPES, E. P.; GUIMAR?ES, J. D.; SIQUEIRA, J. B.; TORRES, C. A. A.; PINHO, R. O.; CARVALHO, G. R. Pregnancy rates and early embryo loss in a comercial embryo transfer program in Mangalarga Marchador Mares. In: 17? Congresso Brasileiro de Reprodu??o Animal, Curitiba, ANAIS..., Paran?, p. 160, 2007. ROOSDALE, P. D.; RICKETTS, S. W. Equine Stud Farm Medicine, Londres, Bailli?re Tindall, 2?ed, p. 564, 1980. ROSER, J. F. The development of antibodies to human chorionic gonadotrofina following its repeated injection in the cyclic mares. Journal of Reproduction and Fertility. Supplement. V. 27, p. 173?179, 1979. RUSSE, I. Oogenesis in cattle and sheep. Bibliotheca anatomica, v. 24, p. 77-92, 1983. SAMPER, J.C. Ultrasonographic Appearance and the Pattern of Uterine Edema to Time Ovulation in Mares, AAEP Proceedings, v. 43, p. 189-191, 1997. SAMPER, J. C. Management and fertility of mares bred with frozen semen. Animal Reproduction Science, v. 68, p. 219-228, 2001. SAMPER, J. C.; JENSEN, S.; SERGEANT, J.;ESTRADA, A. Timing of induction of ovulation in mares treated with ovuplant or chorulon. Journal of Equine Veterinary Science. v. 22, n.7, p. 320-323, 2002. SAMPER, J.C.; PYCOCK, J.F.; MCKINNON, A.O. Current therapy in equine reproduction. Saint Louis: Saunders, 2007. SAMPER, J. C. Induction of estrus and ovulation: why some mares respond and others do not. Theriogenology, v. 70, p. 445-447, 2008. SANTOS, G. O.; NOGUEIRA, B. G.; DEVEZA, R. F. R.; S?, M. A. F.; JACOB, J. C. F. Avalia??o do efeito de diversos par?metros sobre a efici?ncia de um programa comercial de transfer?ncia de embri?es em eq?inos. In: XXII REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRI?ES, Guaruj?. ANAIS... Acta Science Veterinariae, v. 36, n.1, p.s633, 2008. SANTOS, G. O.; S?, M. A. F.; OLIVEIRA, J. P.; MORENO, M. P.; ECKER, M. K. C.; JACOB, J. C. F. Influ?ncia de diferentes doses de hCG sobre a recupera??o embrion?ria em ?guas da ra?a mangalarga marchador. In: XXIV REUNI?O ANUAL DA SOCIEDADE BRASILEIRA DE TECNOLOGIA DE EMBRIOES, Porto de Galinhas. ANAIS... Pernambuco: Acta Scientiae Veterinariae, p. 371, 2010. SENGER, P. L. Pathways to pregnancy and parturition. Ephrata: Current Conceptions, 2?ed., p. 368, 2003. 61 SHARP, D.C. Environmental influences on reproduction in horses. Vet. Clin. N. A. v. 2, p. 207-223, 1980. SIDDIQUI, M. A. R.; GASTAL, E. L.; GASTAL, M. O.; BEG, M. A.; GINTHER, O. J. Effect of hCG in the Presence of hCG Antibodies on the Follicle, Hormone Concentrations, and Oocyte in Mares. Reproduction Domestic Animals. v. 44, p. 474?479, 2009. SIEME, H.; SCHA?FER, T.; STOUT, T.A.E.; KLUG, E.; WABERSKI, D. The effects of different insemination regimes on fertility in mares. Theriogenology, v. 60, p. 1153?64, 2003. SILVA, L. A. T?cnica ultra-sonogr?fica de inje??o intrauterina para transfer?ncia de embri?es em equinos. 2003. 145 p. Tese (Doutorado), Departamento de Zootecnia a Un |
Page generated in 0.0173 seconds